ID A0A0L7M1F1_PLAF4 Unreviewed; 1233 AA.
AC A0A0L7M1F1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0000259|PROSITE:PS51846};
GN ORFNames=PFDG_02569 {ECO:0000313|EMBL:KOB86687.1};
OS Plasmodium falciparum (isolate Dd2).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57267 {ECO:0000313|EMBL:KOB86687.1, ECO:0000313|Proteomes:UP000054282};
RN [1] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., O'Leary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS016347; KOB86687.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L7M1F1; -.
DR EnsemblProtists; KOB86687; KOB86687; PFDG_02569.
DR OMA; HIMTDID; -.
DR Proteomes; UP000054282; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002550; CNNM.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU01193, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054282};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU01193,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|PROSITE-ProRule:PRU01193,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..157
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT REGION 378..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1102..1129
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1233 AA; 142957 MW; BF1BC4C6ACEFB76C CRC64;
MMLDTLQLNL LILVSEKNKK EINNAKNARK ILPLRNNTNE ILVTFITANV MVNSAFSLLL
SEVTDGFTSF IISTLIITIF GEIIPQSICS KHGLAIGGFF APLIYVLKFL LYLFAKPTSL
LLDHFVGKNV LNTYDKKQLK ALVDMHKSAA NILHEDEAKI LVSALELSQY KIVHIMTDID
YVFGIDYNSV INYDSIKRLL RSGFSRIPVI NRNKAECIVG LIHIKDLINI WFGINKIIFD
NRNKLIRNQN IKKNGKIQLF YKKSNTINKN QKDDSLNIDV QGGYYYMKKK SQKIRIANKI
FTFNGQKLYS HKILNDKQND ISSSNKKQNH ITLSQEYLNV KKKFISNYQG IYSNEIYNIN
NNNKENHNII QTDSRSSNNI TNVINSDSTS YDDGSNNEDV KINIGGTSFT NNSSSSNNSS
SNNSCSSITT KKKHTKIINS TLVQDIKGNN KKKNIGNINN SLENHPYNKL ISNQKNKEQI
NKQINTQNKI KNTMDASFIF KHNYYDIGPS DIINPSKLRN KKKQDMKKAP RIITKNKKVN
FVDYLSDNMM DTNDENSTIS SCNEYIYTNI KSKINFYDKN RNKIKTKQLA KLFNKKKKQI
TFRLWDGDKK KKIEKNNKES DHMSNNNNIE NVDNIENVDN IENVENVDNI ENVDNIENVE
NIENVENVDN NNNDEQHKDV QSGEEIIGLI DDDNINLHLK HNNSYYNYND KDKDMNNKHN
YVLNNHKQPG KDIYSSDNIK SDKTINIKNI KTYDKKDPTI QKTKSKTKTN TNTNTKTKWQ
FSQSIMIKEN LNKEKNMKEI YKDIKNFISI NEHKSIEIPL KYILKHIGRY IYGVDYNDSI
LSLLNFFKSA SNHMVVVRKV IYNDNEDPKY AHIGIITLED VIEILLQEEI SDEFDFKKIK
TGSSIPSNFV WKNSDDSKKK MKSKIRRRNH KVVFDEDNVK MIEGLDVHAS QNKISLTTTI
NNNNNNNNIN NNNDDGGGGN SCDNNKIQRS TDVTKLGISP SHKDVLQRAQ TILKYKKDIM
NFLKESIYFK YIDPQLLNQY IQRKKIKTLY KGEILLKDNT FLNYAIILIK GKVKNLSSCQ
SQNIIQDKCF IGLEALGPSN IIELFNQTIE KRNSLIKNIE EEEEKKKKRR RFTFSRTRLT
LKSFRKKETI LKKKKTIATK KIPNQVTKSN THVIKKNINI LFRKWYTQHV YYNKNEYVAE
TTCEYMMIPK SDYMDMIIEC YCNNQVEEII EAS
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