ID A0A0L7M757_PLAF4 Unreviewed; 1741 AA.
AC A0A0L7M757;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=PFDG_03352 {ECO:0000313|EMBL:KOB88702.1};
OS Plasmodium falciparum (isolate Dd2).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57267 {ECO:0000313|EMBL:KOB88702.1, ECO:0000313|Proteomes:UP000054282};
RN [1] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., O'Leary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG701734; KOB88702.1; -; Genomic_DNA.
DR EnsemblProtists; KOB88702; KOB88702; PFDG_03352.
DR OMA; IKLHNYC; -.
DR Proteomes; UP000054282; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24353:SF37; CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX; 1.
DR PANTHER; PTHR24353; CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022527}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054282};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1190..1210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1266..1283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1289..1307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..442
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 518..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1741 AA; 210347 MW; 6D45724CC353244A CRC64;
MYKSKRKNRY YERCRSSEFV LGVQSYSLRP QRTKIKYKNK TCKGVEEMDF GMDMCEEEYI
KKRLSSSYYS YENEYNNIAS KFEKIKKLSH PNICTYFHMS RTNNNYILCS EYYTLSLYDL
LNDEHINCVN FKCFKKIFNK KIYKKNKNIY KIYNNIKNYI YNHNNNNHNH NKIGKKKKII
DNIILNNIIY QILSAVQYLH AHNITFLNLT PHNILITDQG QIKLHNYCLS YLFYNVSSLS
TYKENKNVHY IKNKLYDHVI SKNEMYTGQT TKNNYLDKLF SDQKKKNYKI NNHMILYIDQ
YFKYYNFTHN ILYHIPFLLF FNLLKNENVH FIYDVYKHID IFNIGIIIIQ IVNGLLNFSF
ILENFIYFYH IQTLTNVSYD ERTKQYKQNK KCIKDKLNNI TNNYKQYDLN SFSDSALYIK
QKIICSKEKR KTINIKGSHK YKDKKNQQIY NEKNNETRQK QIPLESYKKK TKKINKEQQT
IEQIYQHALL VKRKIVDIQQ EQKTDNKYIE SNYTNNVKNN QTNKHNAMDP SNNENISSTS
LNKQIILKRD TFNIPRNMSL LENTTITNEK GLMNKVSHIN NFISNACTSH IYTQPFSNTS
HNNNNDDDDN NNNNLYFNSN IKNGHQNITD TNNNIIINTE SERVFNDILL NPNYDNIYFN
SANVREMPPE HVQEINKLSQ EELAKKNYYN PYLVDYILNV TKWNEWKDKY FINKKDIFYW
FHMLYNINYN EELMNVNSFL RSPNILKIPY VLYKRKNGTY FDMSLFSFYK LYLLKKYDSN
TLFNVYENVS TFKKLSKEKY KNIKKIIKHE VNYIKGNKKK SVYTCVPRKR CGNYKEMIYI
STYELLKNRR FTVSKNNMLK KYMFMSNNDG DICNIINKKK EITELWENKK KIHVYEQEYN
ITKKKKRKKK KKRIPLWENK NVVTQSNNKH KSMNNCTHEK TDNIYNSYNE YDDKNYNYDD
DLFISSNFFN ISFNINNKHS YALFNDYNLT TIGIYLKEFY EIIKDAYSFI RRNENFINPK
SSCIYTNSFF FIYQFKLHIK YHELLKFNPL DTLTLIKEIK SGYPCNMRNV IYLILLNYNY
HILLKKSYEK KEKIKDQISY ILISQNKRID KNAIIIYSNN SNVKYCMYSK KYNHKHNNNN
NNNNNNNRLL YIYKDKWIYD NDLIGSLKFQ KKLINLLILI NIKLDIQNKY LKYLFIPIIL
LYYNNIYISY KCIKKILQKY LIDFYKNVYY RNEYIYIFNS LLNYYIPELS MWFFKNNINI
IKIIKSWIYS LFCTFFDLQN IYLLLDNILI QPSSYIIFIC ISILMYLKKY LINITTNENI
YKKVFSLSNL INLNLILNTS RYLFERCPKY YLLFPFHLQI EGSSINEKSI LFDKGGNENI
SNHINYISHL ISNKKWIRYY VHRYTFKLYI KKKNKTKNKN FICINNKTPL IHMNYNTTNT
NEINNNQNYN NQNNLLIEKK KLENININLK DNNDNNNNNN NNNNNNYTNE SFKILKKSYK
TNESLKLKNY YKYFLKCYKT NKQKKNVNEF IYYKKGNFKN CEQRKTKINK QKNNNNNNSN
NTYNNELAKN VNNHNNMNNT YHELAKNIKN IYNTYYELAK NMNNKKKKKK KKFKNVDMVK
LSNFPIFPFL DIRHILNDFC IDDYIIVDMR SLENFKKKKF KSSVHVNTFL INLKKGTYKN
YIDDTSYDEN LTLKTILLVF NNSILDYDAI YNFLNLKIKY ITILCGGFTN ALSILPSTYF
T
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