ID A0A0L7M8I4_PLAF4 Unreviewed; 1552 AA.
AC A0A0L7M8I4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Isoleucine--tRNA ligase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFDG_03827 {ECO:0000313|EMBL:KOB88885.1};
OS Plasmodium falciparum (isolate Dd2).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57267 {ECO:0000313|EMBL:KOB88885.1, ECO:0000313|Proteomes:UP000054282};
RN [1] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., O'Leary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594}.
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DR EMBL; GG701811; KOB88885.1; -; Genomic_DNA.
DR EnsemblProtists; KOB88885; KOB88885; PFDG_03827.
DR OMA; IHLCCEG; -.
DR Proteomes; UP000054282; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR CDD; cd07960; Anticodon_Ia_Ile_BEm; 1.
DR Gene3D; 1.10.730.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 3.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033708; Anticodon_Ile_BEm.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR010663; Znf_FPG/IleRS.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 3.
DR Pfam; PF06827; zf-FPG_IleRS; 1.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000054282}.
FT DOMAIN 167..232
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 289..781
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 1059..1182
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 1232..1370
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT DOMAIN 1520..1545
FT /note="Zinc finger FPG/IleRS-type"
FT /evidence="ECO:0000259|Pfam:PF06827"
FT REGION 1097..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 187287 MW; B6E13F0C91EB6B5F CRC64;
MYVYIYIYIQ KFIQQFWNCK EIYEKRNFEN IKKHIYNNGN NTKQSKYIQH NNTQSCNEHN
ILNKKKKKEK ETYSDVMETK NSHLIKELIE KKKKLISKID DNNNNNNRKH IFKYIKTKDY
INCHNGNHLI NKFENIIYEK IKNEKYLKKN KKEILLKLYN KILNKIKIIH DGPPYANNDI
HIGHILNKVI KDIYLKYFLF QNYFVLLIHG FDTHGLPIEY NVMKLLKINH IQDLNLNSSY
IHNQNESLKN EHVFFKSYIN LLNKLKNQHK KKKQISFLSN IFEKNNIISK DTIEQQKIST
FKNLCKSYAS YFVNEQFMSL VSYGIWGYWN YTYITFYKFY EQIQNKVFRD LLKNKYIYMS
NRPIYHSYAT KTVLSDSEII YKKRVCNSFY FFYTFFKISD TFLLHLLKEF KENKAINEIL
EFNQDDRKII KKVKILVLTT QMHTIFNNKC LLIHEKYLYR IIHLKYEDEK ENQFFIICDK
SYNSFSDNLT KYYSKKSPIK EIKNICTFQG NSFMSCTYKN FTNNEENNFI FVSDNEIKES
FGTGIVHVAP SHGFTDYNFY YKNNKLKKIY LDISNYQEIE EKKQTRDNNK INISCNDMKA
EVSKKIFNEN YFIKNNSLSL DVINENVMDE NDDLKDEYTE LVYKNLEKNI HFIKKYETPS
NAQSLLNSLD IMKKKTKKLN INEKDIHSLF FYSFYENILF YFPYEHSYTY DWRSHTTVQI
KSLLQIYVDI DKIKNNIPFY QSIKNIHFIN KHVKNNLIKT IKDRNEWCIS RQKYWGVNIP
LKDIELDQNQ KIIFNNQIMD VWFDSSVSYI YVLYMCKHIL FHTYFNKIWK SVKNYNNTYQ
KGKGKYKNKI NYNNKNENKL SFNIYDVYDQ IMNHDEYNIR SMENKDNILL KNILQKKKIF
DTSKMYKWIN KQIQKGQQKK YYSFQWNSIK DIVFSKNNKK EFFKKHFNIF LCCEGIDQIR
GWFQSFFFVF FCLNWINQRK KTRSQLLKNT DKIIDKKGVV IIKREQIKNN IKHYTLNNNN
NNDNNNNNNN SIFSDDSLCF NNTSSIETNS KRLPSHSYLP IKNVIVHNYV VDSNNIKMSK
SLNNVISPRE LFFEKEKDDI PTTSKRKDTQ KPDDLNKNTD INNKGNINNN VNNNNDILMK
TGKQIDLIKK KNKNKDLNKR FNADIVRLWV CCYNFVNRNI SISYEILENI NKYIYLKLYN
TFKFIMNNIY DLNFDGTKDN MKIKWDNIQM IDKFILYKKD NLIKHCTKAY KNFQLQLLIK
YIMNFIYTDL AIYIDYSKDR LYIHEKNSLN RTNCQKILYK ILRDLIILLG PIVPHLSEDI
YYNLQLLKNK TKRKYMTTHN NNNNNNISIN EGKIKSLFLR PFPKFKNYKQ VNLDTLFLIK
YYIHKQISPY FSNSLQAIVY IFSNNDNIIN LIKSFLRTPD PLEQFNNYDD LRFLFNVSNI
FICDNICQVE EKDKNYKTYK IPLPNINEKN QIKNKNKNKK KNLNDFFQPN QKPIVDHMLN
FDENIEHAII SIGINKTESK RCSRCWMYGT VYSFEGEYFC PRCLNVIKSH YN
//
