ID A0A0L7QUY6_9HYME Unreviewed; 1711 AA.
AC A0A0L7QUY6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Vitellogenin receptor {ECO:0000313|EMBL:KOC62359.1};
GN ORFNames=WH47_03772 {ECO:0000313|EMBL:KOC62359.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC62359.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC62359.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC62359.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KQ414731; KOC62359.1; -; Genomic_DNA.
DR STRING; 597456.A0A0L7QUY6; -.
DR EnsemblMetazoa; XM_017937688.1; XP_017793177.1; LOC108574999.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 12.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 12.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 12.
DR Pfam; PF00058; Ldl_recept_b; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 12.
DR SMART; SM00135; LY; 11.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 12.
DR SUPFAM; SSF63825; YWTD domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 8.
DR PROSITE; PS50068; LDLRA_2; 12.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KOC62359.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1711
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005574904"
FT TRANSMEM 1633..1656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..274
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 318..362
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 406..449
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 450..492
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1480..1522
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 33..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 45..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 72..84
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 79..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 118..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 130..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 164..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 239..249
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 942..960
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 954..969
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 974..986
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 981..999
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 993..1008
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1013..1025
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1020..1038
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1053..1065
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1060..1078
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1072..1087
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1118..1133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1136..1148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1143..1161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1155..1170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1191..1209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1711 AA; 192858 MW; 9A17B16CB135A511 CRC64;
MYRKLFVVLV LSTIYTHIDT SIIRCDAPEW FSCDNKKCIS SVFRCDGEND CGDDSDEIHC
QGIQIAPETI RCATDEFQCF DRSCIPIEKF CDARPDCPDE SDEYDNCVKD LKCDTFRCND
GHCIRNEWVC DGVADCPDKS DEGKCDNQTI PIDQCTNNYD RYLCKNQRCI SLDLTCNGKD
DCGDHSDENV DQCKKAVETC KQTAKCEHHC RKTPEGAQCS CRSGYKLMDN RTCADVNECE
EYGRCDQRCV NTLGSYICLC QSGYLLNDDK KTCKAEGGEA LMVFSIKSEI HGYYLDSQVY
YPVTRNLQHA VAVSLDANYV YWSDIENGDE AIFRSLEDGS EREVIVTTGL SSPDDIAVDW
VTGNIYFTDS GYMHVGVCNN DGSYCTIIIK ERNDKPRGLA LLPSSGLMYW TEWGMNSCIL
MAGMDGKNST VLIEKDLEWP NSLSIDYANN RLYWIDSKLK VIESIRLDGT DRRIVLKGVA
KKPFSLAVFE NKLYWSDWIS NTIQSCDKFT GKNWEILVNA NSTIYGIHIY HSILKPKLPN
PCNSNPCDQL CLLNSENSYT CACTVDKELN SDQRTCRAMK KKAHLVIAAG NTFIDYYHEL
LGKPKITSSA TLKHVTAVTY DPFTGGLLAS DQLTDMIFHF DTQTGEVKTM MPIEDKLLGG
MDFDYIGNNL YLLDVKHKTI EVHSLNTSEK TTFYFQDEPH GIALIPEESM MMVVFNVDGK
YQIDMMKMNG LGQRITIKSQ LYGPKVSLCY DRDLKRLFWS DQGTGRIGST TVPGFETNLF
RTGLSEPVSL AVLGDHVFWT QYKSNQLYWT SKSSTQQYQK RITLRTPTEL DRMQLIGLHG
TYVNEHQCRK NNGNCSHVCL LSNPHSYICA CPPDMMLNGD NRTCSPQTAC KPGEVKCGEH
DICIKSYQRC DGVRDCPNRE DESSVCEEMH WSKCKHEDEF QCKSGECINN TKRCNSYYDC
ADQSDEEGCD KKECNSNEFQ CHEGACISKY LVCNGLNDCS DATDEINCSK HTCDTDSFAC
ESGACILKTW KCDGEVDCPD GSDESDECQR VGCPSEMYTC SNGRCIDSML KCNGIDECED
NSDEKYCSDF GNKNPVNCTV DEYKCFHTEM CLPKRVRCNG VQDCPKYDDE RNCVRCLPEE
YVCDNQKCID KSWVCDTVND CGDGSDERDC DGGNSRTNDV SVISNCKEFK CSNGVCLPFD
KVCDGKADCL DRSDEFGECA IACTKNNPCS NMCHRTPVGP VCSCRSGYKL SSDLKSCEDI
DECKENSCSQ ICHNTKGSFT CSCNEGYIIR GDRTSCKVAG PQMEIIAVAR NDIRKLSPNL
NSIEVIYEEM NSEISGIDFD ARGETIYWSN DVLGMVSKIH IKSKERKTVT GLGRPEALAV
DWITDNVYFN DNDHFSTIKV CNLEQRKCAK VVSIGSKNRA TAIAVDPRQG WLFWSQTTWT
FYDKPTTEIY RCHTTGTNAT AILYRDIGAV FAMTVDYARS KLYWSDTFLK SIESSNLDGS
NRKLVLNTDN YQALSISVYE DSLYWLMAPT GTVKKCKLYG DKSCTTIPIG NSNVDKYFTI
LHTIRQPIVK NSCEKYTCSY MCVHGKDGPA CICHNGYTKD SNTCMQDTNN KIQFDSSIAS
RRNKDVRQQN GTLFGIITMI LIGLACIVLG LTYFYFRNIK PNCLKKNSLS IHFHNPLSEH
NEDTFLRNCI SGLPTGEHEY VNPLTDIQKV E
//
