ID A0A0L7QXZ2_9HYME Unreviewed; 572 AA.
AC A0A0L7QXZ2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Paraplegin {ECO:0000313|EMBL:KOC63421.1};
GN ORFNames=WH47_01911 {ECO:0000313|EMBL:KOC63421.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC63421.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC63421.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC63421.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR EMBL; KQ414699; KOC63421.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L7QXZ2; -.
DR STRING; 597456.A0A0L7QXZ2; -.
DR EnsemblMetazoa; XM_017936558.1; XP_017792047.1; LOC108574050.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF8; PARAPLEGIN; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 147..287
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 572 AA; 64157 MW; 326BF63B6AFB5D94 CRC64;
MIKVNLKSGA TFKDRWLNPY IHISNSPDFM EIEKKIRAIE KDMGIRMEDG VRIDYIKMDR
NILATNLFYL TTIAIIAYMY FRNPKNRNVF NAFGDISKAK FTLVNPFSGK GVRFKDVAGL
QEAKVEVMEF VDYLKNPERY KKLGAKVPKG ALLLGPPGCG KTLLAKAVAT ESNVPFLSMN
GSEFIEVVGG LGAARVRNLF AEARKRAPSI IYIDEIDAIG KKRSESFAQT ANSESDRTLN
QLLVEMDGMT TAQDIIILAS TNRPDVLDKA LLRRGRFDRH IVIDLPTLEE RIQIFEYHLH
SLALEGKPMQ YATYLAHLTP GFSGAEIANV CNEAALHAAS EAKVKVYNDD LMYSIDKVLG
GTVKKSSTLT PSEKKVVVYH EAGHALAAWL LEHVNPLIKV TVVPRTNKRL GFAQYSDTNL
KLQSSEHLFE RMCVLLGGRV AENIIFNKIS SRAQTDLKKV TEIAYHQVQQ FGMSPSIGLI
SFDKELTSTK TKKPYSKKLA GLMDAEVRRI ITEAYKRTEK LLLDNKDKLI TLAETLLKQE
TLTYKDIEAL IGPPPFGKKD LTKLEEFNAN LE
//
