ID A0A0L7R7T2_9HYME Unreviewed; 2495 AA.
AC A0A0L7R7T2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN ORFNames=WH47_12364 {ECO:0000313|EMBL:KOC66937.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC66937.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC66937.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC66937.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR EMBL; KQ414637; KOC66937.1; -; Genomic_DNA.
DR STRING; 597456.A0A0L7R7T2; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 7.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF527; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00135; LY; 5.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF63825; YWTD domain; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000313|EMBL:KOC66937.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Transferase {ECO:0000313|EMBL:KOC66937.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000312};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1809..1832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..118
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 124..216
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 501..600
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 989..1089
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1493..1596
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1597..1693
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1697..1798
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1893..2162
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 2195..2219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2266..2345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2363..2410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2266..2282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2283..2317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2318..2345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2363..2383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2384..2410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1926
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2495 AA; 280834 MW; 7971A0ECD42C5CA2 CRC64;
MDVIFVSIIP AEIGIPPAPA LVADSLTATS LRLEWKGIDI ERRGGGISYL VQWRYEELAE
TWQYCRNQSW GEDDQILVEN LQPYTKYRFR VALLLKSSQH NPEPIVSAPS VVIRTLAAGL
PTSAPVIVRA VAVDSCRASV SWEPGPFPNG PLLSYVLRLQ GADHSQLKDI AASENTDHYM
FQNLEPNKNY SISVTMRNGV GEGPPAVTHV VTTPEPAVKD TQQPILILGG QHVVMKQDAD
MLDDPSVVYE NTSIIKGVAI HVASAQLFIS DSLGYVYRTS ITKRTKPMVI LSPSQANFKP
LSLSVDWLNL HLYILGEVKH ATTVWQIARC NLDGRGLTVA VAGFLTRPTH IEVDPYNGYL
FWVTRGGLYR LDLADISNGV KHEVQPYLIL EDAHLGAFTV DHTNFRLLVP HHIQNTVISV
SLDGREVLDL RSNTQQPKFK NVVSLAMANG LFYWTNGEEV LIEGYHSGQN RYFHNAYPDR
SNGSFVSVNV LMDASQPVPV PVNPPTGVQA VLGVERAKVS WQAPHLLGGQ GKGAWQNWSY
ELEIKDESTG ETIHQKDIAG SSHTVHNLRE KSEYSIKAAA YTSAGRGPWS TEFRGRTLRD
GSHASILWSA NEGLLRSDVT GENIDTLIYK ASLKEPETDY HIVDVSWYKD ILYIVGNNSA
LYRYNITNHQ KMKMNIHSVG SVAVDWISKK LYWANPKQQI ITRANLNGSQ QEPMSILAIV
KELMIDSLEA YLYWSTGHAV EVARLNGQDR RYYHSDEIFN GKQVMGLTLD TENRYVYWIV
RSYESGSIVY RAPTSEKIPM THKIMPEKVS ALQHPNMQGP LCYFSEHLLW LQDDRNAVIG
DLSGQNTAII NGITLSGLHM VAIMDPALHQ YPKNLSSETV VVLPNAVNYS SIRVEGTWRN
FNISWDPVEN INYGTVFYEV KFADYINTNS NPEITTETSM PYNNSEQILP YSVLEVTVKA
FTYWETAHHT RKILRSPQSI PSQPTNSRAF IEFHKEPLSE NVDIFAIFRW DQPEFTNGLI
TGYTVMCWFK EDHVPIQFCD HKSLIPSTLL EHTVQDLLPN TTYYFQVSAH TEIGAGPYTD
LINVSTIYEN PVPQLLVATM DAVRISDLDQ EVNYTITRHI AVEVTYMAAE NKIYWINEMQ
ELVTSDLNGA NATKMLTLNN SALSITIDWV ARHLYWSESS YRENGGRVMK LDLTMWHDGI
LKYENIIASS RRIVNLDILP STGSLYWIEL TKKDGGIIMQ SDLNGRAIQP FFNHIDDCSC
PYRPSVIPVM TIDSTNYQKP VMYWISMEGH LNIADIDGCA CSLIVSAGFN KGLPPTSLTV
DKMNIYWSNI AEDQIYFVNK KYPDDGEIKH FYLPSVRSIK ALGKSLQTYP ITNCLIPHQV
SYNVEEVKKT ANSITVRLPQ PVPQFGCETY SLPTTLYTIY VSQCLENDPN MCEDSDRTKF
QTYEEEYEIK DLKPFTKYRL KLALSNYYAD LESMSLEFGS GVVLRTEAGA PTAPENVTVE
ALTPTLAVVY WMPPKILNAA AVRYEVHWRL VRLINGARQK GEQFIKGTER TTDGRFFTML
EPWLPDQEYL VFVRAYPAHV NDVYSESPGQ VVKMYPEPNN LTLTGVSVNG LNVTWVPTIN
LTIRYTLEYK DVAVENWQVA NDSKMVNEKL TYFIKKLQPR TLYKFRLILR YPNYKLDFVW
PTDGRFTFQT LGDVPSAPGM PTVTKLRNSV YQLNWEPAQA HGSQITLYRV EGMKINEINE
QIDSSENASW KLFYNGTDNY WIITGDMDDK YRFRVKARNA YGFGGWSRSS PIIDLTETTG
GILAAQQHLG LVLGLSVPVI TIMLICFCYF LCLYRQRKED KKAVLPPLVS DVELATLREI
PRGNFVQSNA LYASTLQNDP DDSTLPKIRR EQITLAKFLG SGAFGEVFQG NAKDLERPGV
TPVAIKTLRK GASAQEKTEF LQEARLMSHF RHKHVLRLLG VCLDTDPPLL VLELMEAGDL
LSYLRASRSL QTSDLHALRL QDLLAMCEDV ARGCRYLEEL HFVHRDLACR NCLVSARDRE
NRVVKIGDFG LARDIYKNDY YRKEGEGLLP VRWMAPESLV DGVFTSQSDV WAFGVLMWEI
TSLGQQPYPA RTNLEVLHHV RAGGRLPKPM NCPPGLHQLM LRCWSAADAR PSFKACLEHI
VSLRSTIEDA PLSPVHAGHY LARRGVSNMA YFADENQNHN NSGNSWKSSS SEGSRDMQPF
LQNSHNATLT LQSGEVPKYL ELLADNEDII PRENSTNGYE VPRSIHISDQ NLANTNKVGT
NSDAKRDNLH PESTLQEQKD NPGDTKEQSE KKCDKRSSIS SLNLPERKRA SITSMTDKCN
TLDSSKLTNP TIKAILKRDS FTSLTDQRKN KRNATERRGS EISLEGRSTS SLSSNISLAP
PTRPSSSLIS SQNVLPLKNS VIGGDSTLND GNVTKNTLPK IQRTHSNLQN GKANIPLVIN
SALLNLLRQT PVVEDSNNIV TYTNINTDAV RVNGS
//
