ID A0A0L7R9C9_9HYME Unreviewed; 1369 AA.
AC A0A0L7R9C9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Protein toll {ECO:0000313|EMBL:KOC67361.1};
GN ORFNames=WH47_09278 {ECO:0000313|EMBL:KOC67361.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC67361.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC67361.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC67361.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KQ414628; KOC67361.1; -; Genomic_DNA.
DR RefSeq; XP_017787887.1; XM_017932398.1.
DR STRING; 597456.A0A0L7R9C9; -.
DR EnsemblMetazoa; XM_017932398.1; XP_017787887.1; LOC108570525.
DR GeneID; 108570525; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF22; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 20.
DR SMART; SM00013; LRRNT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 4.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 9.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1369
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005575156"
FT TRANSMEM 992..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1062..1201
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1273..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1369
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1369 AA; 154198 MW; 80F94F5A9D3C6165 CRC64;
MTAKYVFMTL INAAFLCLAS TILSESAGAS CKWLSEGGND TRSADCNLRV LDPGAITSLI
SSLDGALKLR IRCSDVHHFE SSLNAQSWQR LTSLHELHVH GCKVLRIQDG AFQPLLELKR
LTVQTFNAIW GASRFLELTP NSLLGLRELH TLEIIESNVQ ALPVNLLCGL DNLQTLNLTG
NRLRDMNDIG LNRRDDKLPT DGTEETSCRA DIRFLDLSRN DISRLEENSP LLGLRQLQEL
YLQRNQILEI ATDSLTGLSA LHIFNASCNS LESLPEGLFA STRDLRQIHL AYNELRDLPK
GIFTQLEQLL ILDLAGNRLC SDQVDETTFL GLIRLIVLDL SYNTLTYIDA RMFKDLFFLQ
ILDLRNNTID RIESNAFLPL YNLHTLELSN NKLHTVGAQL FNGLFVLNRL TLSGNSIASI
DPLAFRNCSD LKELDLSGNE LTSVPDALRD LALLKTLDLG ENRISNFYNG SFRNLDQLTG
LRLIGNDIGN LSRGMLWDLP NLQILNLARN KVQHVERYAF ERNSRLEAIR LDGNFLSDIN
GVFTSIASLL LLNLSENHIE WFDYAFIPGN LKWLDIHGNF IENLGNYYEI RDSKVKTLDA
SHNRITELSP LSVPASVELL FINNNYISVV RPNTFTDKVN LTRVDMYANM IEMMELTSLL
LTKVPEERAL PEFYIGGNPF NCNCSMDWLP AINNQTSTRE YPRIMDLDNV MCGTSGPRGV
AIVSASLARS EQFLCRYEAH CFTLCQCCDF DACDCEMTCP AGCKCYNDRT WNTNAVDCSG
LNVDEIPRRI PMDATEVYLD GNVLRELQNH VFIGRKNMRV LYVNASDIES IQNRTFNGLN
NLQILHLEDN RIRELKGFEF ERLSHLRELY LQNNLIGFIG NLTFLPLRSL EILRLSGNRL
VTFPVWQVTL NARLVELSLG SNPWSCRCKF LQELSSWVSD NAHKVVDASD VWCYYGGDAR
PAYRRRLNVN ETLCSDYFSQ GGVIESIMVS DYLPLVAATL SAVLVLLLII VLAFIFREPV
GAWAYSKYGL RFLRTKPGKS TGTATMPSAA PMTACCDTDR ERLYDCYVCY SPNDEDFVLH
SLAVELEHGT AGLRLCLHHR DLPCVLRASA PAVVLEAVDA SRRVLIVLTR NFLQTEWSRF
EFREALHEAL RGRAAQLIVV QAGHACSEVE RDHELRPYLR TASAILTWGE KRFWERLRYA
IPPANTMADI SMESKSSPLV YKRNINTYTL DGVGSEKTSM STLRSQERQR ALFKDSSPTT
ALMLQHAPPA YSCGTVSVPQ QQQPPPSSPQ PRLTVNHAYR DAVNVPGSNL IATNTTMSSG
SSEDHRRPLS EHIYSSIDSD YSTLERTAWR HQQPPPPPPP PSSGQAYLV
//
