ID A0A0L7R9U8_9HYME Unreviewed; 1261 AA.
AC A0A0L7R9U8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Dosage compensation regulator {ECO:0000313|EMBL:KOC67531.1};
GN ORFNames=WH47_00376 {ECO:0000313|EMBL:KOC67531.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC67531.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC67531.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC67531.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; KQ414625; KOC67531.1; -; Genomic_DNA.
DR STRING; 597456.A0A0L7R9U8; -.
DR EnsemblMetazoa; XM_017932231.1; XP_017787720.1; LOC108570377.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 3..71
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 164..236
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 394..560
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 635..808
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 585..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 141318 MW; 02C6E8B03585D9ED CRC64;
MGDIKSFFHQ WCAKHSTEPQ FDVRPTGPKH RQRFLCELRV SGFDYVGAGN STNKKDAQGN
AARDYVNYLV RTGHVNPSDV PRETVNNQQN DSAPIIVKIE SLNCKSVFQD GMGPNDIGHA
YRAYNEHGQG NYTYMDRIAD QKKVEDAEDV DVNSGIHGNW TIENAKSKLH QFMQTNKINA
DYKYTSLGPD HTRSFMAEMT FYVKQLGRNI TGRETGSNKQ TASKSCALSL VRQLYHLGVI
EPFSGTLKKN KEAEQIKPYP VKISPDLVNQ IHDVLLSLNI QPVTVKSEMM SSLNQDLNQS
GNTISLLTNQ VLDDFISSVP QPAGVVSWSP PQQNWNPWTG CNIDEGPLAT KTLEQMSEEL
LYEQRERLQQ DDSLQKSIKE RSNLPVFSMK NEIMNAINEN PIIIIRGNTG CGKTTQVCQF
ILDDYVASGQ GAFCSIAITQ PRRISAVSVA DRVASERCEN LGQSVGYSVR FESCLPRPYG
SIMFCTVGVL LRKLEGGLRG VSHVIVDEIH ERDVNSDFIM VVLRDMIHMY PDLRIILMSA
TIDTTLFSNY FNNCPVIEIP GRSYPVEQYF LEDCIQLTNF VPPMDSKKRK NRDSDDLPTE
GEPEENLNKV IDPSFSIQTK NAMAQLTEKE ISFELIEALL KSIKEHDTPG AVLIFLPGWN
LIFALMKHLQ QHPIYGGSGY VIIPLHSQLP REDQRKVFDP VPPGITKIIL ATNIAETSIT
INDVVFVIDS CKAKMKLFTS HNNMTNYATV WASRTNLEQR KGRAGRVRPG YCFHLCSKAR
FNKMDEHMTP EMFRTPLHEL ALSIKLLRLG SIGKFLSKAI EPPPIDAVIE AEVILREMKC
LDENDELTPL GKILARLPIE PRLGKMMILG CIFRVGDALS TMAANSTTFP EVYNMGPDVR
RLSTQQKWFA GARFSDHVAM LHAFQAWEEA RSGGEYAEQT FCDSKNLSLP TLRVTWEAKN
QLQALLQSAG FPEETLCPTP LNYQAGADVR LDTITALLCM GLYPNVCYHK EKRKVLTTES
KAALIHKTSV NCSNFEQNFP FPFFVFGEKI RTRAVSCKQM TMVSPIHLLL FGSRKVELAD
GVVKLDNWIN LDMDPNHAAT IVALRPALES LVVKAAKEPE TILELSSNEE KVLSVIKSLC
GMNACRYELE QITGGGFQSR RPPRGHATGF YSDSTSPAKM MRGGGGYRGX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX SWSLLIIILN NLQCEISKNL
L
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