ID A0A0L7RBD6_9HYME Unreviewed; 519 AA.
AC A0A0L7RBD6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 13-SEP-2023, entry version 33.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:KOC68061.1};
GN ORFNames=WH47_03219 {ECO:0000313|EMBL:KOC68061.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC68061.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC68061.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC68061.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ414617; KOC68061.1; -; Genomic_DNA.
DR RefSeq; XP_017799133.1; XM_017943644.1.
DR AlphaFoldDB; A0A0L7RBD6; -.
DR STRING; 597456.A0A0L7RBD6; -.
DR EnsemblMetazoa; XM_017943644.1; XP_017799133.1; LOC108579994.
DR GeneID; 108579994; -.
DR OrthoDB; 5362214at2759; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF0; SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 354..449
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 444..493
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 122..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 58836 MW; FBA83586E52255C0 CRC64;
MGQHFASLRE FFRMDSERQS LEACTNVIQP AQLEVMLQLE NLHDNENNGN VPALNLNLIL
HEECKADGNL DNDHLSLDLD NHNSRFETLY SQPVETQESK EICSNGNITN ELCFKQQKAC
CSSSGDSNTS SKSEDSPINP PLRRSSKTLS FVKRKGKQRS KDQSQMCTHV LSSKKKRSSW
VLKFNCAKNK SSKSSDIIPG QGNNSSDCVC IGHRRTEEHP MGAGVIFNSR SAPQSPVLGP
LPPSPVIDLS RFNPEEFPME DCDERARLQR AREMEEGVEP PPGYKPNYPS GIQVHPNGIT
VDSLAALFQA HSVLTALSQI DFTLIPSIGR PAHTQVDYVH CLVPDLKSIT ACSFYWGKID
RYEAERLLEG KQEGTFLLRD SAQEEFIFSV SFRKYGRSLH ARIEQWNHKF SFDAHDPGVY
ASETVCGLIE HYKDPSCSMF FEPMLTIPLH RNFAFPLQHI CRGVITTRTT YDGINKLQLP
KTLKSYLKEY HYKQRVRVRR LDTENDLQSY GRSISYLPL
//
