ID A0A0L7RGE6_9HYME Unreviewed; 1279 AA.
AC A0A0L7RGE6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Atrial natriuretic peptide-converting enzyme {ECO:0000313|EMBL:KOC69873.1};
GN ORFNames=WH47_07083 {ECO:0000313|EMBL:KOC69873.1};
OS Habropoda laboriosa.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Habropoda.
OX NCBI_TaxID=597456 {ECO:0000313|EMBL:KOC69873.1, ECO:0000313|Proteomes:UP000053825};
RN [1] {ECO:0000313|EMBL:KOC69873.1, ECO:0000313|Proteomes:UP000053825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0110345459 {ECO:0000313|EMBL:KOC69873.1};
RA Pan H., Kapheim K.;
RT "The genome of Habropoda laboriosa.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ414598; KOC69873.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L7RGE6; -.
DR STRING; 597456.A0A0L7RGE6; -.
DR Proteomes; UP000053825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00112; LDLa; 5.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR24252:SF8; ACROSIN; 1.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053825};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 239..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 919..975
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1041..1273
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 743..758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 769..787
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 781..796
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 801..813
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 808..826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 820..835
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 859..874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 876..888
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 883..901
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 895..910
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1279 AA; 143209 MW; 885465427B237002 CRC64;
MSTADGMDNP AFASEEECTT EAKLDDGQQQ VTLDQDHKSE GGPVENGHQR SQFVSQQYVE
AGRTSPDAPY RNETRIDLPE NNDKTVVEPK MNGVHGNGNN NDASFLNNSA TSVQINDTGK
KEQIEAVNLE LVSMRPYAGN NLQTKGQEAC EVPADPYEEY FVPVNEHRKY ISRGPEAEVE
TTVAGVRFDL GPGVGREGLS LRDPAAGLVD YSHWLTALRG EKLYVTKDKR SRSSYWRRMA
CWGCGLLVLL VAVIIAILAA TGVILTQEAS EPLENLQQTN SRQFGDVRTA GSQEYVKDPP
SSPPPATSSF PPWPTTDETI YDTVPSALEG LLKLDDFRWN DDLSDPKSRV YRQVSSEIEE
RLKNMMQQPA DNDTVVKVYD ISRNGEVRFR ISYPPQSMPE ETQQIIEQTL QLSSNMIGQY
HLNSLKVNKL VDQCRTGGFG CSEWCEYNYS KGLFVCSCKT GKVLDNDGKT CIDENDLSNV
EMDDEIPESN TEAVHDYVQG RSRGPGTVFE PRRPDNWDHL DFTTEKTSAG YGSSQNENEH
EFHMHDSSAE PVATTEQNRV FKEESDPVHW AHDHSMHDDS MHDDSMHDHS MHDHSMHDHS
MHDHPMDDHS MHDQSMHDHA MHDHSMHDHS MHDHSMHNHS MHNHSMHDHS MHDQSMHDHS
MHDHSMHDHS AHEHLEQNTY TTITPTMYTK IPDAVVESTS HIDVSFLNLP PNVVFSKCTA
GQFQCVNGTS RDGAYCVQLS AKCDSENDCS DGSDELNCEE EGCPGNFQCA SGQCLKRDLV
CNKIVDCNDG SDEKNCEHWK CQFDEFRCPS GRCIPSIWQC DGRPDCEDHR DEYNCAESCG
NDKYLCPTEK WCIPLTWHCN GISECANGED EKLCDCALDQ FKCQTGGCVP ENQVCDGIEH
CPDHSDEWGC LMTNMTMERN LTEGQKEDEG NGNQEFGDRS SLLKIRQYNG EYRLVCSDGW
SEELSNSYCQ ALGFSGSEST ELKAWDKNQK ILRLKSNPNH RMPLVTNLEQ MEFCVSDKVV
QVSCQEFSCG SHYGEGPTAR LVGGTPASEG QWSGVALLKK PKHGAACTAS VLGPMHVLAS
YSCIHRHKQS SGWQLFTGEN LLKAHPVRNI IPYPQVKYNQ FLYNNDIALV ELEKPLTFSR
NVSAVCLPKH PIQPRQICVM VGWGFSVNGE VDLQKYLNFL PLPTLETEKC NATSHYAGFI
TKDNICAGFT DTDKGPCYND EGAPLMCVSE SGGGSAKWEI QGLLSHHSRC SRGHPAIYSS
VEPALSWLRH SVPALQTQS
//
