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Database: UniProt
Entry: A0A0L7SVW4_9GAMM
LinkDB: A0A0L7SVW4_9GAMM
Original site: A0A0L7SVW4_9GAMM 
ID   A0A0L7SVW4_9GAMM        Unreviewed;       404 AA.
AC   A0A0L7SVW4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
DE   Flags: Fragment;
GN   Name=thrA {ECO:0000313|EMBL:KOC87284.1};
GN   ORFNames=NG42_21270 {ECO:0000313|EMBL:KOC87284.1};
OS   Erwinia iniecta.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=1560201 {ECO:0000313|EMBL:KOC87284.1, ECO:0000313|Proteomes:UP000037088};
RN   [1] {ECO:0000313|EMBL:KOC87284.1, ECO:0000313|Proteomes:UP000037088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B120 {ECO:0000313|EMBL:KOC87284.1,
RC   ECO:0000313|Proteomes:UP000037088};
RX   PubMed=26198254;
RA   Campillo T., Luna E., Portier P., Fischer-Le Saux M., Lapitan N.,
RA   Tisserat N.A., Leach J.E.;
RT   "Erwinia iniecta sp. nov., isolated from Russian wheat aphids
RT   (Diuraphis noxia).";
RL   Int. J. Syst. Evol. Microbiol. 0:0-0(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KOC87284.1}.
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DR   EMBL; JRXE01000046; KOC87284.1; -; Genomic_DNA.
DR   EnsemblBacteria; KOC87284; KOC87284; NG42_21270.
DR   PATRIC; fig|1560201.3.peg.4508; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000037088; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000037088};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Kinase {ECO:0000313|EMBL:KOC87284.1};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:KOC87284.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037088};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Transferase {ECO:0000313|EMBL:KOC87284.1}.
FT   DOMAIN        1     62       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      56     61       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    266    266       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     139    139       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     163    163       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     251    251       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KOC87284.1}.
SQ   SEQUENCE   404 AA;  43936 MW;  4BAE517556D80A82 CRC64;
     FSALARANIN IVAIAQGSSE RSISVVVSNE DATTGVRVVH QMLFATDQVI EVFVVGVGGV
     GGALIDQLYR QQAWLKKKHI DLRVCGIANS KALLTNVHGV ALENWKEALA AAKEPFSLER
     LSRLAKEYHL LNPVIVDCTS SQAVADQYAD FLADGFHVVT PNKKANTSSW NYYQQMRAAA
     AKSRRKFLYD TNVGAGLPVI ENLQNLLNAG DELIRFSGIL SGSLSFIFGK LDEGVSLSEA
     TKLARELGFT EPDPRDDLSG MDVARKLLIL AREAGYQLEL SDIEIEAVLP DSLNQIADVE
     SFMQRLPELD EAFAARVAAA RDEGKVLRFV GAIEEGGVCK VKIDAVDGND PLYKVKNGEN
     ALAFYSRYYQ PIPLVLRGYG AGNDVTAAGV FADLLRTLSW KLGV
//
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