ID   A0A0L8FFT6_OCTBM        Unreviewed;       638 AA.
AC   A0A0L8FFT6;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE   Flags: Fragment;
GN   ORFNames=OCBIM_22022763mg {ECO:0000313|EMBL:KOF62583.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF62583.1};
RN   [1] {ECO:0000313|EMBL:KOF62583.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF62583.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF62583.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   EMBL; KQ432990; KOF62583.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L8FFT6; -.
DR   STRING; 37653.A0A0L8FFT6; -.
DR   EnsemblMetazoa; Ocbimv22022763m; Ocbimv22022763m.p; Ocbimv22022763m.g.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          6..351
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          348..478
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          615..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KOF62583.1"
SQ   SEQUENCE   638 AA;  72481 MW;  40B461081EF8017E CRC64;
     HYSYEKKLER LLWKINFKDI VFLTSPDDVM DLPNKSSLKK SMTRWSFLQP NPSSGATPSN
     AKPFYKSQQV SVKFIGKKSV ELTRAMKRRM QLLKEMQHEN INRFIGACVD PPNCCIVRQY
     CARNLGELLH NKDIRLDNMF ISSLVADLIK GMLYIHDSDI ICHGNLKPSN CLVDARWVLQ
     ITDFGVNTLG EAEECCLESM EDEKYYNRLL YTAPELLRSA CRNLNGTQKG DSYSFALILY
     EIHTRHGPWE STNLSKCGRL SVTQCDKADP LNYRHNRNRK KPNIYDHIMG LMEKHAENLE
     ILVAHRTIEL EEEKKRSENL LMRMLPRSVA ESLKIGSPVI PEQYQSVTIY FSDIAGFTSL
     SALSTPLQVV DLLNDLYTCF DSIIGDYSVY KVETIGDAYM VVSGLPERNG DMHAGEIASM
     SIHLLSAIKH FKIRHRPHER IKLRIGIHSG PCVAGVVGHR MPRYCLFGDT VNTASRMEST
     GVDGDSMISL HRCMHICDVF FSSVGCGSPR MFITINIFSH LGKGKGQMFT YFLVGEDQRY
     RLRRLNECVK EPLNGITLTK SCSSSKLIRM LSEQNDVNMD YLDDNDDVFF TNGQDADYSE
     NLNLLPSLTK FTGRSMSTSS SSSQSGKPLI HYQLPSEQ
//