ID   A0A0L8FG65_OCTBM        Unreviewed;       993 AA.
AC   A0A0L8FG65;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=FH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=OCBIM_22022235mg {ECO:0000313|EMBL:KOF62698.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF62698.1};
RN   [1] {ECO:0000313|EMBL:KOF62698.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF62698.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF62698.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC       subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR   EMBL; KQ432638; KOF62698.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L8FG65; -.
DR   EnsemblMetazoa; Ocbimv22022233m; Ocbimv22022233m.p; Ocbimv22022235m.g.
DR   EnsemblMetazoa; XM_014934596.1; XP_014790082.1; LOC106883550.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.20.58.630; -; 1.
DR   Gene3D; 6.10.30.30; -; 1.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR   PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}.
FT   DOMAIN          1..325
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          518..911
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   REGION          412..517
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          953..993
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          357..398
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          792..819
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          892..925
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        424..507
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        955..981
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   993 AA;  112944 MW;  C15A4C7C06A94376 CRC64;
     MLDIQDEKKK MLENQAKSSK QNVLRTPEHF IASLQDPSLK GEKRLKVLES ARVSLSSNPV
     SWAIEFGSNG LNEILRNLTY CCDLKQERRS TYECVRCLKV FMNNQVGLLK FINHEEALTI
     LARTIDPSDA TTMLEAVRLI AAICLVTPSG HDKALEGITS CAEIRSQPRF QPIIKGLEMT
     DNLPMQVACI QLVNAIVSTP DDLEFRIHLR NEFIRTGLNN ILEKFDKPQE FEDLKTQLHV
     FHTQADEDSE DFFQRYENIK IELSSIEDCY GLLMNSINNT PSSTYFLSIL QHFLLIREES
     YVKLEYFKLI EECVSQIILH KHGMDPDFSY TKRFELDIED LLEQISNDKV GEDNAKIEEM
     NNMLELELTA RQEAEAKFLT LQDKMKKLET ENSQMKEKIN SGIGAMINKT IGGSDGNIPN
     SGGVPRAPPL PGSSTVPPPP PLPNMGGRVP LPPPLPGGAP RAPPLPGSIP IPPPPPGVPR
     APPPPGVPRA PPPPGVPRAP FPPGFPAPGM KKDKTLPRRK KYNVDVKIKR INWTQVNMKN
     FHENSFWAHI NEEKFANDRL IDEIRNRFSM KTQEKTTVKE KPMKKTKELK VLDIKSAQNL
     SILLGSVKLP YEEIKRCILQ VDLENLSQHI LEQLLNYLPP QDAINQLGTM KDNYNELAES
     EQFMVVISDI KSVNQRVSSL LFRVKYEEII NDIKPSIVAI TQAFDQVRSS AKFSSIMTLI
     LSIGNYMNTG SRNAESIGFE ISYLNKLKDT KTQDGSMTLL HFIAQIIQDD YPELEKFGDD
     LTYIEKASKS SDEQLQKNLK AFKKNLNQLE IDLKNAANSK LQGDKFVEKL EPFLDDAKTQ
     YDVLNTMYKQ MDMKYTELAN YFTFDRKKYS SEEFFHDIKE FQSSFDHALK ENKQQKETLA
     NIARAKEAKE ARERERKEKL QRQKQFMDVN ADEPNHGVVD NLLEALTSGS AFNMNREKRE
     GKRRVPRPGG AERRAHIRPR GCMTRETSGT SVC
//