ID   A0A0L8FS79_OCTBM        Unreviewed;      1170 AA.
AC   A0A0L8FS79;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=FH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=OCBIM_22009446mg {ECO:0000313|EMBL:KOF67534.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF67534.1};
RN   [1] {ECO:0000313|EMBL:KOF67534.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF67534.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF67534.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the formin homology family.
CC       {ECO:0000256|ARBA:ARBA00023449}.
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DR   EMBL; KQ426997; KOF67534.1; -; Genomic_DNA.
DR   RefSeq; XP_014787404.1; XM_014931918.1.
DR   AlphaFoldDB; A0A0L8FS79; -.
DR   STRING; 37653.A0A0L8FS79; -.
DR   EnsemblMetazoa; Ocbimv22009446m; Ocbimv22009446m.p; Ocbimv22009446m.g.
DR   EnsemblMetazoa; XM_014931918.1; XP_014787404.1; LOC106881506.
DR   GeneID; 106881506; -.
DR   OMA; TISAWDI; -.
DR   OrthoDB; 3035921at2759; -.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR043592; FMNL_animal.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR   PANTHER; PTHR45857:SF4; FORMIN-LIKE PROTEIN; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          173..566
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          621..1005
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   REGION          18..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          503..558
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        20..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1170 AA;  134005 MW;  265D43D2AC92A011 CRC64;
     MEAVSDFLSR HDFQESETDV DFIETSPSSS TKSSDMFFNS ISSSSNDGGQ LSDLDSSGVH
     SGSFSVSSSP KVNNSKDSDR DSGRLSIPDS ASEYSLTETI SAWDISMPSV SPVTSHLNLH
     YSEDDLSKYE DKSGKKDKIR SRKDKIMMSI KTFKKKIMKL SKTNREPGDE TDTSKPSEES
     LYQWVVDTLS QLDNGGSNSD NEQKMLSRST NVVPIYIECL KKCIEKNLLS CSTSDVYSAT
     QFEKFKGSLN EINPISYVLQ KLKGDLRIAE ENFVLEYINK PNRGMILMVH LLQDIQVAGM
     SLSETASLMA NQGLMYDEYQ QQLDDEHDCL LCLKYMLRFK TAIHKFLDIR HSLETVSHSL
     INGISKTKLA ALQIFTICLT EVNGLNCVLD TFSYICFKFG EPMRFKLLMN MLKNTTSQQL
     SFQVACLKFV NSMLNATSTL NHRVFLQHQL LAAGLDIDFL EKQETEGNGC ELAELHHEIT
     NWKTNFINVE NIQEEQIMAE SRNSILRREV DILQAKMKNI QNDFESSKSH LTEASKKSKD
     YQERVFELQE KMETLMQLYE EKTGQLAGKN IIADVLRSVE SPEFTPVRRD SSASVTSAVT
     NVIPAPPPVP PIRENNSNYS SKRKFEPKVN LPVLNWLPLN NVRKTIFEEL SDDVIYKEID
     FSDFESKFQI SNNNNNAFNR SFKSVRKLKN RLKVLDNHRA RNLVITQRKI GHSAHQIREY
     IDKYDTKSLH GDYAELLLKY VPTKDEAKIL SRYSKDYFTL DMSEQLMYQL SHIDRVENKL
     KVMTFMGQYP DIVNNLKPQI TKITECSKSL ADNAKLKKIF EIILAFGNYM NSSKRGCING
     FKLESLTKLC QIKSKDNNQT LLEYLVDIIC CYYPTLIFWY DDIDLHIKRS ASYQSIAVDI
     FTLRKGIDLM KFEREKNTSI NETLETFYNM ATTEMHTVWE SFKLMEESYK DICSKFGENY
     KIIDPGLFFS YFSDFAQHFK KALEKSFGSN QLTADSKSFS MSAIYQQTDS DSTSSGGLNA
     LKSSQTRRSY TKFKQGAFSA GSRYGSKRYI NSNERRKEEK RRSLRREIPV LTNSSNSKQY
     HSVRSTRELQ NLVARGLRSY KSLSCLADVN LSKTANIKEQ YANRLNNDLS SQHILPVQYD
     YKGIGNKITY IHFTDKQMQK DSDSDEVTCL
//