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Database: UniProt
Entry: A0A0L8FTL7_OCTBM
LinkDB: A0A0L8FTL7_OCTBM
Original site: A0A0L8FTL7_OCTBM 
ID   A0A0L8FTL7_OCTBM        Unreviewed;      1102 AA.
AC   A0A0L8FTL7;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   05-JUN-2019, entry version 20.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=OCBIM_22008897mg {ECO:0000313|EMBL:KOF67745.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Cephalopoda; Coleoidea;
OC   Neocoleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae;
OC   Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF67745.1, ECO:0000313|Proteomes:UP000053454};
RN   [1] {ECO:0000313|Proteomes:UP000053454}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Albertin C.B., Simakov O., Mitros T., Wang Z.Y., Pungot J.R.,
RA   Edsinger-Gonzalez E., Brenner S., Ragsdale C.W., Rokhsar D.S.;
RT   "WGS assembly of Octopus bimaculoides.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KQ426798; KOF67745.1; -; Genomic_DNA.
DR   RefSeq; XP_014787230.1; XM_014931744.1.
DR   EnsemblMetazoa; Ocbimv22008897m; Ocbimv22008897m.p; Ocbimv22008897m.g.
DR   GeneID; 106881377; -.
DR   KEGG; obi:106881377; -.
DR   KO; K02327; -.
DR   OMA; CLVNYTE; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000053454; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053454};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053454};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      118    475       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      540    970       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1009   1080       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     32       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0L8FTL7}.
FT   COMPBIAS      1     26       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A0L8FTL7}.
SQ   SEQUENCE   1102 AA;  125269 MW;  64AFFBF7F83CDAE5 CRC64;
     MSSGKRFPDK RDSSNPMKKP KYDDDDDEIP SMFEQDLEML DQMESELLMG SESTDFVDDE
     TDVSQKWARP PLPSIIDPAK DSVVFQQISV DYYIGAPMQG MPGSSIGPVP IIRMFGITME
     GNSVLAHIHG FAAYFYVPAQ SGFKKEHCQQ FKNALNKAVM KDLRSNREDI KEAVLGVEYT
     TKESIYGFHD NRKEPFLKIT VALPRLIAPA KRLLEQGFQC LDYACHGFQT YESNIDFEIR
     FMVDKGVVGC NWIELPKGKY QIRSKNSQSP NTPGNPAIKS HCQLEVDISW EDFISYPAEG
     EWSKVAPFRI LSFDIECAGR KGIFPEADKD PVIQIANMVV RQGKSEPFIR NVYTLKKCAP
     VIGAQVLSYD SEKELLKNWS SFIRSVDPDI VTGYNIQNFD FPYLINRAKH LDVTNFPFLG
     RIRNQRSVIK ESTIQSKQMG KRENKIINIE GRVMFDLLQV LLRDYKLRSY TLNAVSFHFL
     QEQKEDVQHS IITDLQNGTE QTRRRLAIYC LKDAILPLRL LEKLMCVINY MEMARVTGVP
     LPYLLSRGQQ IKVISQLLRK CREQDLLLPV QKMTTGDEYE GATVIEPTKG YYSFPIATLD
     FSSLYPSIMI AHNLCYTTLL NQNTIKNLGL TSDQYIKTPS GNLFVKSTLR KGLLPEILND
     LLSARKRAKA DLKKETDPLK KRVLDGRQLA LKISANSVYG FTGAQVGKLP CLEISQSVTA
     FGRMMIELTK QYVEEKYDTE NGYEHKAKVI YGDTDSVMCN FGVETVAEAM ELGKEAAEYI
     SSKFIKPIKL EFEKVYFPYL LINKKRYAGL YWTNPNKYDK MDCKGIETVR RDNSPLVANL
     INSCLKMLLI DRNPDGAVEY AKQTISDLLC NRIDISQLVI TKELTKSDKD YAAKQAHVEL
     ANRIKKRNPG SAPQLGDRVP YVIIAAPKNT AAYLKSEDPI YVLENNIPID TEYYLTNQLS
     KPLLRIFEPI LGEKKAESVL LRGDHTRTKT LVISKVGGLA AFTKKKSTCI GCKAVLDSGN
     KAVCKHCKSQ ESAIYQKEIC QLSALEERFS RLWTQCQRCQ GSLHEDVICT SQDCPIFYMR
     KKVQKDVSDQ GKLLHRFGHI DW
//
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