ID A0A0L8FX69_OCTBM Unreviewed; 1742 AA.
AC A0A0L8FX69;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Kinesin-like protein unc-104 {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22005183mg {ECO:0000313|EMBL:KOF69336.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF69336.1};
RN [1] {ECO:0000313|EMBL:KOF69336.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF69336.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF69336.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; KQ425538; KOF69336.1; -; Genomic_DNA.
DR EMBL; KQ425538; KOF69341.1; -; Genomic_DNA.
DR RefSeq; XP_014786054.1; XM_014930568.1.
DR EnsemblMetazoa; Ocbimv22005179m; Ocbimv22005179m.p; Ocbimv22005183m.g.
DR EnsemblMetazoa; Ocbimv22005184m; Ocbimv22005184m.p; Ocbimv22005183m.g.
DR EnsemblMetazoa; XM_014930568.1; XP_014786054.1; LOC106880568.
DR OrthoDB; 126886at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22705; FHA_KIF1; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 2.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 3..356
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1628..1726
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 935..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1557..1599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 623..650
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1428..1468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1742 AA; 198259 MW; 978CD40BC3C5AE83 CRC64;
MSSVKVAVRV RPFNSREIAR DSTCIIDMCG TTTTIQNPKP GPKDQMYKSF NFDYSYWSHT
DPSDPEFSSQ TKVYEDIGLE MLDHAFEGYN VCIFAYGQTG AGKSYTMMGK NEDSQRGIIP
LLCQDLFDRI KDNKTAEQMY SVEVSYMEIY CERVRDLLNP SNKNNLRVRE HPLLGPYVED
LSKLAVQSFE DIGKLIDEGN KARTVAATNM NETSSRSHAV FTIIFTQKKL DQATKMVGEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALADVSA EGIKVSSKKK
KKTDFIPYRD SVLTWLLREN LGGNSKTAMV AALSPADINF DETLSTLRYA DRAKQIVCKA
VVNEDPNAKV IRELKEEVAR LRELLVHEGI EINECNTPTG QKEIKRTRKE SMSTDGDDPV
ERLQLSEKLM AELNESWEEK LRKTEAIRKD REAVLAEMGV ALREDGGTIG VFSPKKTPHL
VNLNEDPLMS ECLIYYIKDG ITRVGLPNTK QPPDIQLNGT HIKEDHCMFD NNEGTVTVIP
SNGSIIYVNG RQITEPTILK VGARVILGKN HVFRFNHPVQ ARESRALMTE SITDLESLSQ
NQEPVDWTFA QLELLENQGI DLRKDMEQRL LALEEQYRKE KEEADMLFEQ QRKDYEFQIH
ALQEQVERHS MMSSFTTDDF NEEEDHQMEC TWTDHERQIA VWAFRKWKYH QFTSLRDDLW
GNAIFLKESN AISVELNKKV QFQFVLLTDT NYSPLSSELL PQDERDSNRP FPKTIVAVEV
QDLKNGATHF WSLEKLRQRL ELMREMYHNE AELSPTSPEP SIDNMTGGDP FYDRFPWFRL
VGRSFVYLSN LFYPVPLVHR VAIVNEKGDV KGYLCVAVQA VTEKEDTVDY APGIKQSGNA
KISFDDDNYF EKKQLYSPKL AQDCSNLKKA VELPPQEEER IVEGEGTSPD SNEMLEEGKV
NVDNTRESAD YFPDIADKEL PEHLKIGSVF QFRVTVLKAS GISPEYADIF CQFNFLHRHD
EAFSTEPLKN SGKELPLSFY HVQNFTVTVT KSFIDYIKSQ HLVFEVFGHY QQHPLHEQAK
ENLLCSGSPL YSNIRRPPRR SFPMSLPVSK PVPSPKFGVI TPPSASEANI PLNSLVMEIN
KSLTNCTSPV HAKYDLLVWF EICELAPNGE YVPTVVDHSD DLPCAGTYLL HQGIQRRITI
TIVHEKGPDL IWRDIKELVV GRIRNTLDYR DVDSENTVLS LSLFPAHYVQ QPNDDRIFFR
FEAAWDSSLH NSPLLNRVTP YGEKVFMTLS AYLEVDNCAQ PAYITKDLCL LIHARDGKLT
APRSLRNLFS GGYSRKDTNR LGGVYELFLR RCNNSGSPGV QRRQRRVLDT SSTYVRGEEN
LNGWRPRGDS LILEHQWELE KLTRLEMVEK ARHILLLRKK LGEQNKTQEL SKLDKDASNM
YAKAKSQRAK EEELKGDDDK DLSTDGTDKK LKFSNPGGPI PDFVTNGDAN KELTAKCLRL
LLQGRLPLSS QNKPVTALNE SMVSSNSDED ETAPMSMDNV MQASTSSSVL NTSLNNSNQN
CSMDSSVTSD ILRPTSTETK TQSKSCESLS SMAENSERKF SLPLKTNKPE TDQQLFIPDI
EEVRVSPIVS RKGYLNFLEE KTNGWTKRWV VVRRPYVYIY NNEKDPVERG LINLATAQIE
YSEDQQAMLK TRNTFSVMTK HRGFFLQTLD DKDFHDWLYA INPLLAGRIR SKLSRRKQSV
KI
//
