ID A0A0L8FYI6_OCTBM Unreviewed; 506 AA.
AC A0A0L8FYI6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|ARBA:ARBA00012134};
DE EC=1.4.4.2 {ECO:0000256|ARBA:ARBA00012134};
DE Flags: Fragment;
GN ORFNames=OCBIM_22004389mg {ECO:0000313|EMBL:KOF69629.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF69629.1};
RN [1] {ECO:0000313|EMBL:KOF69629.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF69629.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF69629.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; KQ425289; KOF69629.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8FYI6; -.
DR STRING; 37653.A0A0L8FYI6; -.
DR EnsemblMetazoa; Ocbimv22004389m; Ocbimv22004389m.p; Ocbimv22004389m.g.
DR EnsemblMetazoa; XM_014930346.1; XP_014785832.1; LOC106880430.
DR OMA; MHINLHK; -.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro.
DR CDD; cd00613; GDC-P; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR049316; GDC-P_C.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF21478; GcvP2_C; 1.
DR Pfam; PF02347; GDC-P; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 6..259
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
FT DOMAIN 307..428
FT /note="Glycine dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21478"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOF69629.1"
SQ SEQUENCE 506 AA; 56187 MW; 0848E027397EFFF7 CRC64;
YTRYHSETNI VRYMKMLENK DLSLVHSMIP LGSCTMKLNA SSELIPCSWN EFTSLHPFAP
KEQAEGYIEM FKSLEKDLCE ITGFDKISFQ PNSGAQGEYA GLCSIMAYLS DHGETQRNVC
LIPISAHGTN PASAQMAGMK IQVVRVAADG AIDKEHLKEM VEKHKDTLAC LMVTYPSTHG
VFDEDIREIC DLIHSHGGFV YLDGANMNAQ VGLCRPGDYG ADVCHLNLHK TFCIPHGGGG
PGMGPIGVKK LLAPYLPGHP VIDPFDSGES SSKSLGVISA APYGSSLILP ISWTYIKMMG
PQGLKKASQL AILCANYMSY RLKGHYKILY TNKNNLVAHE FIVDCRPFKK LANVEAVDIA
KRLQDYGFHA PTMSWPVTGT LMLEPTECED KDELDRYCDS LIAIRQEIQD ITDGKLDRKV
NPLTMAPHSQ SVVMATNWDR PYSREIAAFP ASFIRPENKR WPAVGRIDDV YGDQNLVCSC
PPMEAYESPF MKESANENLQ ERRASN
//
