ID A0A0L8G533_OCTBM Unreviewed; 244 AA.
AC A0A0L8G533;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=OCBIM_22000203mg {ECO:0000313|EMBL:KOF71998.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF71998.1};
RN [1] {ECO:0000313|EMBL:KOF71998.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF71998.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF71998.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; KQ423898; KOF71998.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8G533; -.
DR STRING; 37653.A0A0L8G533; -.
DR EnsemblMetazoa; Ocbimv22000203m; Ocbimv22000203m.p; Ocbimv22000203m.g.
DR EnsemblMetazoa; XM_014928596.1; XP_014784082.1; LOC106879157.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00678; PI3KINASEP85.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 115..206
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 244 AA; 27437 MW; AA30D815B5A996DF CRC64;
MSHTGVMEAL GKTLQDIRGI NKSMVGVVTL VLSGDFRQTL PVIVRRTRSD EIKACMKSSY
LWNKVLKFSF TTNVLLLQNG MSQDFLDNQL EGRKENDNSS VSDDLPHRQE SLWLMSCQRD
EAEKLLEGKP DGTFLIRPKN NGQFYALSIV HEKVIGHCKI LRKNGNYGFA EPYIIHPSLL
ELVLHYQKTS LSEHNEHLDV TLKFPLKAGI MAEDVSGSGG DALYARMTSM NLSSNQCPPW
DHDG
//
