ID A0A0L8G5P5_OCTBM Unreviewed; 1272 AA.
AC A0A0L8G5P5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=OCBIM_22000306mg {ECO:0000313|EMBL:KOF71910.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF71910.1};
RN [1] {ECO:0000313|EMBL:KOF71910.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF71910.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF71910.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; KQ423917; KOF71910.1; -; Genomic_DNA.
DR RefSeq; XP_014784170.1; XM_014928684.1.
DR AlphaFoldDB; A0A0L8G5P5; -.
DR STRING; 37653.A0A0L8G5P5; -.
DR EnsemblMetazoa; Ocbimv22000306m; Ocbimv22000306m.p; Ocbimv22000306m.g.
DR EnsemblMetazoa; XM_014928684.1; XP_014784170.1; LOC106879211.
DR OMA; WIQTQTA; -.
DR OrthoDB; 1614410at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR24416:SF564; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1272
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005582898"
FT TRANSMEM 872..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..429
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 976..1239
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 1009
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1272 AA; 143996 MW; 8B444C87DD292F5A CRC64;
MQFLLLLLGC FFLTKGSLSS LSSFKAGYGK LSKISINSKT NDVYVGGVNG IYHLDRELKV
LQSLNIKPVS NSAVNNTVTV LAIEPNLEYL LVCGTIKKGA CRFYNLDDMT TKKVTSDTRN
ASLIGNQKSV VAFFEKSQTS VPYMYVAMAY DGRAISDYPF TISERKIEKI NQYHKISFRN
NLKYVKANRN VPVEFIYGFK YNNFIFYVSV RNNNSTYLLR VCEEDENYYY IEMKLHCWLS
DYKIHYSTAA RFTYIEGKPV LLVAYWSEEH KRSAVCEHDM IEVKRKIKQT ISSCSKNSHE
FPKTSPWIIT NEYCSEVVHD GITEETCGIA NNVYISKRKP IAVTASFNLS TYITAIQLYT
WEHRPVYLLG TIDGHLLKIR KTTIENKFHI VMDYDVSEGS GHPIERDLEL IGNKTAYMLS
GSKVTRFPLV SCNVYSSCRT CVTANDVTKC GWCKNKCTTH SACKESAWYP DFCKPVITSI
YPKSGPFEGR TVLTIKGDYF TNINDENAII QVHIKDKECL VLEYNETMIK CLTQKQKDNV
SSIHVTAKAV SKVSNQPNIS GQNSSDEFFY FYKPEIYNFT PKFGPKSGGT RCTITGTKLN
IGSSATVMIK SRNFTIVKRT DTEIIAKTPS VDYPVQGSLI VIIDGSIMKQ TDKFNYTEDP
TISHVNSTHS IQSGGISIEF SGTNLNTVTE PRLSGITVES KQPLSTEPCH SNKEGTWLYC
KSPKIPGRST KQIIPVDTHL LMDGVVDLYN LSTTKPMISR FRYYPDPIIK RFSGDNNVFE
YSTSAKEVEI KGMNITLVAR SKDIDITIDG RIPCKITKLA LSFIKCVPQN MPSRNVTKKF
KLKVKVNIGY LSYEVGWLLY VDTKSVFAST TVIALIVALC VILILIAVTC YCLWKKKVFS
KKRQIPHTAR YFNGGEVSLD VFGRLLPTTT NEYTERQDSP GATTYATGAT SGIPLIDEDT
FLLLKDQKLL IPKEALLMKD KIGQGHFGCV HRAFLFKPGE KGESLVAVKT LHKDNPREID
VKAFLTEAII MKDFDHENIL SLIGICLGKD QMPLVVLPYM LHGDLLSYLR DVNNQPTIKD
LIVFGISIAS GMDYLSGLKF VHRDLAARNC MLDEKLVVKV ADFGLSRDIY ERDYYSSDNK
KSKLPVKWMA LESLETGNYN IKTDVWSYGV VLWELFTRGV NPYPTVDNWD MPKFLKSGRR
MDKPDYCPSK TYEIMLRCWQ VDQNLRPDFA TIVEELTELS QIEKHGDIAI SQIMCYENVN
FALNNNIKPT VV
//
