ID A0A0L8G8I2_OCTBM Unreviewed; 462 AA.
AC A0A0L8G8I2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
DE Flags: Fragment;
GN ORFNames=OCBIM_22038289mg {ECO:0000313|EMBL:KOF73178.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF73178.1};
RN [1] {ECO:0000313|EMBL:KOF73178.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF73178.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF73178.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; KQ423260; KOF73178.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8G8I2; -.
DR ESTHER; octbm-a0a0l8g8i2; Pancreatic_lipase.
DR EnsemblMetazoa; Ocbimv22038289m; Ocbimv22038289m.p; Ocbimv22038289m.g.
DR EnsemblMetazoa; XM_014927747.1; XP_014783233.1; LOC106878519.
DR OMA; FAAYPCA; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR002331; Lipase_panc.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610:SF178; FI22312P1; 1.
DR PANTHER; PTHR11610; LIPASE; 1.
DR Pfam; PF00151; Lipase; 1.
DR Pfam; PF01477; PLAT; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00823; PANCLIPASE.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 340..460
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT ACT_SITE 158
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 181
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 273
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT BINDING 195
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 197
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 200
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOF73178.1"
SQ SEQUENCE 462 AA; 51296 MW; BB25AC730DE69FEA CRC64;
SIFDTEVCFG ELGCFSNEGE FVSLERPINL LPNKPQEIGT QFFLYTRSNP LTGAALETHN
DSLLHLSNFT ATRPTKFIIH GYKSFGKDKP WVLNVTRELL KHGDYNVIVV DWRNGSDVTY
ARAASNCRVV GAQIALLINY IQNQTASTPQ TMHLIGHSLG AHIAGYAGER LENLARISGL
DPSAPYFEHT GSKVRLDPTD AEFVDVIHTD IGYVLGLGLG INGQSGHVDF YPNGGRYQPG
CTEYKIPGSI IGGIVGLLNK LKPGAKAAFM CSHKRAEVLY TESINSACPF NSYSCSDVHD
IKSGKCFHKH GQLGRLGFHA EKVLGRGKHM LQTFDTQPYC AYHYQVTISG KSTIDGRIFI
TLTGTKGTSE RLEMTDHNTL VSPDEKFVHF LISRTDVGHL QYVDLEYDET DNLINIIFSD
DWKLESFQIF QGESEENSIF CVSGTTITSR KSRRYQVSTK CP
//
