ID A0A0L8GG85_OCTBM Unreviewed; 178 AA.
AC A0A0L8GG85;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=AP complex mu/sigma subunit domain-containing protein {ECO:0000259|Pfam:PF01217};
DE Flags: Fragment;
GN ORFNames=OCBIM_22033866mg {ECO:0000313|EMBL:KOF76027.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF76027.1};
RN [1] {ECO:0000313|EMBL:KOF76027.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF76027.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF76027.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to lysosomes. In concert with the BLOC-1
CC complex, AP-3 is required to target cargos into vesicles assembled at
CC cell bodies for delivery into neurites and nerve terminals.
CC {ECO:0000256|ARBA:ARBA00025605}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000256|ARBA:ARBA00006972}.
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DR EMBL; KQ421896; KOF76027.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8GG85; -.
DR STRING; 37653.A0A0L8GG85; -.
DR EnsemblMetazoa; Ocbimv22033866m; Ocbimv22033866m.p; Ocbimv22033866m.g.
DR OMA; THFNEDM; -.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006896; P:Golgi to vacuole transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd14834; AP3_sigma; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR027155; APS3.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY; 1.
DR PANTHER; PTHR11753:SF2; ADAPTOR PROTEIN COMPLEX AP-3 SMALL CHAIN SIGMA3; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 7..135
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOF76027.1"
SQ SEQUENCE 178 AA; 20226 MW; 6BE1A6A10CF92FA6 CRC64;
KKKQNLYFLV QPEDVQQQII RETFHLVSKR DDNVCNFLEG GTLIGGADFK LIYRHYATLY
FVFCVDSSES ELGILDLIQV FVETLDKCFE NVCELDLIFH VDKVHYILSE LVMGGMVLET
NMSEILTRID EQNKLEKTEA GIAAAPARAV SAVKEMNIPQ KIKDIKLPDL PSIGNLKF
//
