ID   A0A0L8GIA8_OCTBM        Unreviewed;      1139 AA.
AC   A0A0L8GIA8;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=OCBIM_22033064mg {ECO:0000313|EMBL:KOF76688.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF76688.1};
RN   [1] {ECO:0000313|EMBL:KOF76688.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF76688.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF76688.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; KQ421721; KOF76688.1; -; Genomic_DNA.
DR   RefSeq; XP_014780765.1; XM_014925279.1.
DR   AlphaFoldDB; A0A0L8GIA8; -.
DR   STRING; 37653.A0A0L8GIA8; -.
DR   EnsemblMetazoa; Ocbimv22033064m; Ocbimv22033064m.p; Ocbimv22033064m.g.
DR   EnsemblMetazoa; XM_014925279.1; XP_014780765.1; LOC106876658.
DR   GeneID; 106876658; -.
DR   KEGG; obi:106876658; -.
DR   OMA; PRIEIRI; -.
DR   OrthoDB; 927694at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   PANTHER; PTHR24373:SF275; VASORIN; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF01582; TIR; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SMART; SM00082; LRRCT; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR   PROSITE; PS51450; LRR; 2.
DR   PROSITE; PS50104; TIR; 2.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..1139
FT                   /note="TIR domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005583017"
FT   TRANSMEM        766..791
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          818..951
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   DOMAIN          988..1121
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1139 AA;  131976 MW;  8CE3A1204F320D44 CRC64;
     MEAGVCLKIQ LLCSLLSTCF FKLILSNQIE NNTVLCKYDF RKLSETRLFS IDGKRLETTA
     RAFSDIKTTS SENECVIELK HLNIPRIEIR ILIYYFKCSD ELTVRLDTTD VETMPRNILY
     LQFQSCLMSQ EDVGKLESLY DLRVLTYFKT IPSSAIWSGS NETDNVNGID NVVSYSIIGD
     RNYSSTLPWV LTANKTYPTI AEITLDGIGL TELPDEMRIR FPNLQSLEIP NNKLIEIPKF
     PYTERTYKLP LGLSRTPFMQ NHYADVFGIK VKPNYFRRIL NLYGNQITNL PDNCTSGSLQ
     MLSLEENGVV NISDHAFSNM YGLDTLTLAN NLLIQIGEKQ FSYCNDLQSL NLKFNKISWI
     HSRAFRHNKN LLKLDLSNNK LVSLEEGIFT ALDNMKTLNL EYNQIQNLSC KSLPLSSIKL
     EEINLRNNNL ETLPICFFLI RRLKQVDLSF NQIAMGKVSN LLGLINSSEL IHSVVYSASS
     SVDLFRKPEE RRLIDLSYNQ IHRLDFSNFT ESNRHTMLLI LLNFELRFTG NLIECDCHLL
     PLLDFFITHR EKHFDGSEYF YHKWKCDSPS EFKNTPILSL KKEQLYCSEA MPHCPTNCMC
     YRRLVQKTVI VDCRYRKITV FPLTMPDGKL EVWLQFNNIT KLVNRPYLSQ ITHLNLTKNS
     ITSLNYTVMR NMVNLKQMIL DWNLLTTLPK GIQNVQFEVL SINHNHFFCD CTNIWLKKWL
     QKSRESILNW RRIVCNTVGD KVLDIVVVPN DKFICNNPND NFKKTLTLGL SLALAILILL
     VCLFLLIHYW LEIKVILYVY LNIHPFDSNP AKIDDGLEPI DTLIVYSKSL SEWATENIIK
     NLEKLSFNVL DTNRDLLIGM SFQENMRVAV SRSKYCIIVL SEESIEDPLV QIALSYTYEK
     TLYGRPTYII LILHNIKRNV VKNKNLKKYL YSGRFIKSTD HMMEKKLLYM LTGRNLYNNH
     DIPLRRRKSY KEFFPEVLGS ANTLNEQKKY DIFISYPDQT YQFATGPLLS TLQSRGYSIC
     LPDRDFVVGS AKEENILRAI KSSVRTLIVI TKSHVEDEWQ LFTLRTAVQC SLKKPFNYLL
     CILDGIVDKS KLDLETQAYV TSHVVIDKDD PLLWKKLFRS IPPARTIENS TSAFDSRKS
//