ID A0A0L8GN43_OCTBM Unreviewed; 727 AA.
AC A0A0L8GN43;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=phosphatidylinositol-3-phosphatase {ECO:0000256|ARBA:ARBA00013038};
DE EC=3.1.3.64 {ECO:0000256|ARBA:ARBA00013038};
DE AltName: Full=Phosphatidylinositol-3-phosphate phosphatase {ECO:0000256|ARBA:ARBA00031219};
GN ORFNames=OCBIM_22031022mg {ECO:0000313|EMBL:KOF78274.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF78274.1};
RN [1] {ECO:0000313|EMBL:KOF78274.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF78274.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF78274.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; KQ421144; KOF78274.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8GN43; -.
DR EnsemblMetazoa; Ocbimv22031024m; Ocbimv22031024m.p; Ocbimv22031022m.g.
DR EnsemblMetazoa; XM_014924131.1; XP_014779617.1; LOC106875841.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14533; PTP-MTMR3-like; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF75; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 3: Inferred from homology;
FT DOMAIN 1..279
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 85..129
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 509..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 116
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 29..32
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 54..55
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 116..122
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 727 AA; 80598 MW; 99211E5284F7CF9F CRC64;
MTMGIRENST NALGMLIIDA RSYSAAIANR AKGGGCECAE YYPNCEIQFM NLANIHSIRK
SFCALRTLCG SSPDQTNWLS GLENTKWLHH IANLLKAACV VASAIHKEGR PVLVHCSDGW
DRTPQIVALA ELLLDPYYRT SYGFYVLVER EWLQFGHKFA DRCGHDVNNG DSNERCPVFL
QWLDCVHQIY RQFPCAFEFS EAFLIKLVQH TYSRLFGTFL CNNANERKKA KLKTKTASVW
SLLLPGNKRF TNSLYNPSTD QVLYPSCHVL NLTLWTHVFL SNNSFSTSSD DIVGTNASDH
FLDEQHKVDH NNLGKTRSYD DLVGVEHPAY FSRRLSDPNI AVDNHEQAMF PAKECSNSVY
SLINVNSNHL LEETSASPPQ ELFNGNHCAS TPDSEPADNI EEGNTEMEYQ IKFGEELLNG
DILTNLTNSE VNGNSSLPSF ITSVSSKSHR TLNKSSQVSV NETFSNSIAP IVDEPLNKLT
NFRNTCTAKT SSSSSSSTAN LPANVYMNGN IEHQNSSSSS NSSSSSSSSS SSSEEDDYSA
KCNAERTLQI YSSISTSTSD ISDSRIDANG GDSSSSSAVP PAVSPAETEY RSIPRSSLKF
NYLFESKMNI SKTKSCPSTP NIPMAQCLKR ALTPVTPAAE SKVQPLLKQC STAQNQTSFN
VTRHLDPDGL TTHPDTVQQR VNEIRSDYHQ TIEIQKRHLE QLATLYQASA FNGTVRQISD
KDELKLW
//
