ID   A0A0L8GSY6_OCTBM        Unreviewed;       752 AA.
AC   A0A0L8GSY6;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=5' exonuclease Apollo {ECO:0000256|ARBA:ARBA00039555};
DE            EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
DE   AltName: Full=DNA cross-link repair 1B protein {ECO:0000256|ARBA:ARBA00041693};
DE   AltName: Full=SNM1 homolog B {ECO:0000256|ARBA:ARBA00042738};
GN   ORFNames=OCBIM_22028364mg {ECO:0000313|EMBL:KOF80156.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF80156.1};
RN   [1] {ECO:0000313|EMBL:KOF80156.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF80156.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF80156.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00001526};
CC   -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC       {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC       family. {ECO:0000256|ARBA:ARBA00010304}.
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DR   EMBL; KQ420477; KOF80156.1; -; Genomic_DNA.
DR   RefSeq; XP_014778254.1; XM_014922768.1.
DR   AlphaFoldDB; A0A0L8GSY6; -.
DR   STRING; 37653.A0A0L8GSY6; -.
DR   EnsemblMetazoa; Ocbimv22028364m; Ocbimv22028364m.p; Ocbimv22028364m.g.
DR   EnsemblMetazoa; XM_014922768.1; XP_014778254.1; LOC106874870.
DR   GeneID; 106874870; -.
DR   KEGG; obi:106874870; -.
DR   OrthoDB; 23465at2759; -.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.12650; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR011084; DRMBL.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR23240:SF8; 5' EXONUCLEASE APOLLO; 1.
DR   PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR   Pfam; PF07522; DRMBL; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT   DOMAIN          271..307
FT                   /note="DNA repair metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF07522"
FT   REGION          384..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          618..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..410
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..431
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  85437 MW;  9B7E3BD70066B28F CRC64;
     MNGHIIKGTP IAVDFWQIRK CPDAKLFFLT HFHSDHTVGL TSSWNQPIYC SKVTGDLICK
     KFSIAQELIH PLELDTPVLI PIDSTNSEIV TVVAIDANHC PGSVMLLFQG YFGCMLYTGD
     FRYEPKVITD SYLSSLNYSV DTLYLDNTFC DPKCKFQTRT QATDWIMELI SYYPGHDIIF
     GMSSLGKPNL LIEIAKHFQE FIAVPQKMFE YFELIETPDV FQIDTVEHEC RLRVVPFYLV
     TEKYLDKLAK PTVAIFPTAL YEGLDGSPYC NQNDIYVIPY SDHSSYPELV EFVKRINPKQ
     IIPIVSANAK GPFKISLSHR ADMSCFNQYL STSPIKKYTM PTFLKNPILP IPGDNAKKIW
     SSAVKKKIQR SVLRRRIPKG VVFESPIKSS QNPKEKSDHL EPKINEENHK NITSVSENSP
     NSSKTDSNSK TVEALQMSSL NIVNRNSDCD IQDIVTGISI MKTPTKSNKQ NKFIGRNSEI
     PDSSKENFAE KISLFENQSQ QSSDNSEEQE ASVPLFDLNV IENICRTNAN NGKRSEKPFK
     ISKTAANCRE QLPMLEQLNE VSVNNNLDER EKETEDIDDE IIRDSENLVA ESVNCGNSSS
     DSNMSTIYDL NEPGVVKENT GKKESVSSKK RKRPFSVGQH LKDYSRLSKR PKEVDNVRIE
     PRSFYSNLCA LSSNGNCKMT KQYNNQRQRL VSSFIEQDKN PVENNPSTSK PSLDFTTKHV
     LSRCHGLQSS VIEKYQNIIE KFVLKQRKMN LL
//