ID A0A0L8H098_OCTBM Unreviewed; 875 AA.
AC A0A0L8H098;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Histone-lysine N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22024870mg {ECO:0000313|EMBL:KOF82711.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF82711.1};
RN [1] {ECO:0000313|EMBL:KOF82711.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF82711.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF82711.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR EMBL; KQ419644; KOF82711.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8H098; -.
DR STRING; 37653.A0A0L8H098; -.
DR EnsemblMetazoa; Ocbimv22024870m; Ocbimv22024870m.p; Ocbimv22024870m.g.
DR EnsemblMetazoa; XM_014921017.1; XP_014776503.1; LOC106873585.
DR OMA; LLCCDCE; -.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd10517; SET_SETDB1; 1.
DR CDD; cd20382; Tudor_SETDB1_rpt1; 1.
DR CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR041292; Tudor_4.
DR InterPro; IPR041291; TUDOR_5.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF18358; Tudor_4; 1.
DR Pfam; PF18359; Tudor_5; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 323..391
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 453..525
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 528..850
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 859..875
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 178..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..693
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..779
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 99988 MW; D2D60CD2D8CE3FD0 CRC64;
MYRDEEANPS TSFYAGIVAE VPTNRNRHRF LIFFDDGYAQ YCLPKEIHRV YEQSKNVWED
IHPDSQEFIK EYLAQYPERP MVQLQKNQVV KTEWMGEWWT AKVVEVDASL VKMYFSADKR
TEWIYRGSTR LEPLFSALAR AETNKLTGFK NKRQRLVAAS RGNKPVVEYT RAQTVEIDDE
DTHITNKVSR TQHGPDQKKR SVAKKSTTSH NSQNGTGANS WEAPWLKMQR NPKSSSASAE
KKREQYQTSS ISSHKQGRDM ASVLQERLAA QTDGDLDEDA LGERIDIDNI ISPRNMLRKK
LIPHECSPEC VKDCDDKDFH IKFRGRNMLL VPTLCGWERQ VTKVRPSAKR IVIYRGPCAR
RMRNLDEVDK YLLATNCNLS IDLFTFDPNL HTHTEFVPIK TFCDIKDISY GKENVPVSCV
NGIDRQYPAY VEYSTKRYPA KGVHLNLDEE FLISCDCTDG CRDRTKCACI QMTIEATTAS
PGGHADESVG YKYRRLNEPI LTGIYECSSR CKCDYRCFNK VAQNGLQLRL QVFKTEKRGW
GLRCLDDIPT GGFICIYAGQ LLTEQGANED GQQYGDEYLA ELDYIEVVEK HKEGYESEVV
DLDDAESTSY SSLSSNSSRS SNTADQDHSD KKTTENGSEE KLGKLVLKRE ANKDKEWSVK
IQGSSQRTAD WVDSLNNEPI VIDDDEDEEE DNTQTTKSDS SAATPIPATK RGNIFTILEE
KKEPTPNADE LPDLEEKLPG LGLRKCTRST TRSRFKNLPN PKDGKNPSKE RIEEREQRPS
TRYYFNDGQL CYVMDAKSMG NLGRFLNHSC SPNVFVQNVF VDTHDLRFPW VAFFAGQYIR
AGTELTWDYN YEVGSVPGKI LYCYCSSAEC RGRLL
//
