ID A0A0L8H7R7_OCTBM Unreviewed; 338 AA.
AC A0A0L8H7R7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Cathepsin L {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22020644mg {ECO:0000313|EMBL:KOF85242.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF85242.1};
RN [1] {ECO:0000313|EMBL:KOF85242.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF85242.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF85242.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ418945; KOF85242.1; -; Genomic_DNA.
DR RefSeq; XP_014774749.1; XM_014919263.1.
DR AlphaFoldDB; A0A0L8H7R7; -.
DR STRING; 37653.A0A0L8H7R7; -.
DR EnsemblMetazoa; Ocbimv22020644m; Ocbimv22020644m.p; Ocbimv22020644m.g.
DR EnsemblMetazoa; XM_014919263.1; XP_014774749.1; LOC106872318.
DR GeneID; 106872318; -.
DR KEGG; obi:106872318; -.
DR OMA; PKTHFRY; -.
DR OrthoDB; 5472948at2759; -.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF971; CATHEPSIN L-RELATED; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..338
FT /note="Cathepsin L"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018703679"
FT DOMAIN 29..89
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 118..337
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 338 AA; 37926 MW; 9C6ACBF5480E5D65 CRC64;
MFNFLAILLV ATCVVAYPFD TSSYLDDEWA IFKNAFNKIY ETESEEYFRR LVWEKNHLFV
LAHNSAAKQK KVHFTVAMNK YGDRTQKEFR ETMNGYKGSS KTNLKSASVD SDDALVYLPK
TVDWRNEGYV TPVKDQKECG SCYAFSSTGS LEGQHFKKTG RLVSLSEQNI VDCSGPEGNN
GCNGGLMDQA FQYIEENGGI DTEAAYPYEA VTKECRFVKN GTGATDIGFH DIESGSEYQL
QKAVSHVGPI SVAIDASDVR FRFYKEGVYY NSECSDENLD HGVLVVGYGV DEKDESVTDY
WLVKNSWGES WGEEGYIKMA RNMDNNCGIA TKASYPLV
//