ID A0A0L8HCS2_OCTBM Unreviewed; 685 AA.
AC A0A0L8HCS2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN ORFNames=OCBIM_22017857mg {ECO:0000313|EMBL:KOF86869.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF86869.1};
RN [1] {ECO:0000313|EMBL:KOF86869.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF86869.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF86869.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR EMBL; KQ418552; KOF86869.1; -; Genomic_DNA.
DR RefSeq; XP_014773581.1; XM_014918095.1.
DR AlphaFoldDB; A0A0L8HCS2; -.
DR STRING; 37653.A0A0L8HCS2; -.
DR EnsemblMetazoa; Ocbimv22017856m; Ocbimv22017856m.p; Ocbimv22017857m.g.
DR EnsemblMetazoa; XM_014918095.1; XP_014773581.1; LOC106871585.
DR GeneID; 106871585; -.
DR OMA; DHWWHDL; -.
DR OrthoDB; 144557at2759; -.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF244; ACETYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147}.
FT DOMAIN 24..84
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 91..511
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 566..644
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 685 AA; 77087 MW; 9E1DF7ED7C3F30BB CRC64;
MANKEFLPPS HLKGSAHVSS MAQYKQMYEQ SISDPESFWR EIAKDLHWES QPSGKFLDYN
FDHTSGPIFI KWMQGAKTNV AYNVLDRHIQ NGKGDKIAFY WEGNDVMDEK KITFSELKTE
VCRFANVLKD FGVQKGDRVS LYMPMILELV VAMLACARLG VIHSIVFAGF SAEALTNRIL
DTKCCAIVTA DGMWRGTKLI NLKNIADEAI KRCKENGYNI DHCIVVRHLS PNPNELRNGS
SCTQQIPAKR PCYDLKINWD SSRDKWWHDL LSTKTDEESK KCPPVWCDAE DPLFMLYTSG
STGKPKGVLH TTGGYMLYAY TTFKYVFDYH DDDVFWCTAD IGWITGHSYV CYGPLVNGST
SVIFEGVPYY PTAGRFWEIV EKYKVTKFYT APTAIRCLMK YGDEFVNNHD VSSLKVLGSV
GEPINPEAWL WYHNVVGKGK CAVVDTFWQT ETGGHVLTPL PGATPTKPGS ATFPFFGVRP
AILTAEGKEV KGPVEEGYLV FKQPWPGMMR TVYGNHERFE TTYFKKFPGF YCTGDGARRD
EDDYIWITGR IDDMVNVSGH LISTAEVEAA IAEHSAVAEA AVVSHPHSVK GECTYGFVIL
NDGFELTEKL ITELKCKVRT KIGPFAQPDY IQYAPGLPKT RSGKIMRRIL RKIAVGDTDF
GDISTLADES VLELILKHRP QTIKA
//