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Database: UniProt
Entry: A0A0L8HCS2_OCTBM
LinkDB: A0A0L8HCS2_OCTBM
Original site: A0A0L8HCS2_OCTBM 
ID   A0A0L8HCS2_OCTBM        Unreviewed;       685 AA.
AC   A0A0L8HCS2;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE            EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN   ORFNames=OCBIM_22017857mg {ECO:0000313|EMBL:KOF86869.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF86869.1};
RN   [1] {ECO:0000313|EMBL:KOF86869.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF86869.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF86869.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:456215; EC=6.2.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU361147};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR   EMBL; KQ418552; KOF86869.1; -; Genomic_DNA.
DR   RefSeq; XP_014773581.1; XM_014918095.1.
DR   AlphaFoldDB; A0A0L8HCS2; -.
DR   STRING; 37653.A0A0L8HCS2; -.
DR   EnsemblMetazoa; Ocbimv22017856m; Ocbimv22017856m.p; Ocbimv22017857m.g.
DR   EnsemblMetazoa; XM_014918095.1; XP_014773581.1; LOC106871585.
DR   GeneID; 106871585; -.
DR   OMA; DHWWHDL; -.
DR   OrthoDB; 144557at2759; -.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF244; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361147}.
FT   DOMAIN          24..84
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          91..511
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          566..644
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   685 AA;  77087 MW;  9E1DF7ED7C3F30BB CRC64;
     MANKEFLPPS HLKGSAHVSS MAQYKQMYEQ SISDPESFWR EIAKDLHWES QPSGKFLDYN
     FDHTSGPIFI KWMQGAKTNV AYNVLDRHIQ NGKGDKIAFY WEGNDVMDEK KITFSELKTE
     VCRFANVLKD FGVQKGDRVS LYMPMILELV VAMLACARLG VIHSIVFAGF SAEALTNRIL
     DTKCCAIVTA DGMWRGTKLI NLKNIADEAI KRCKENGYNI DHCIVVRHLS PNPNELRNGS
     SCTQQIPAKR PCYDLKINWD SSRDKWWHDL LSTKTDEESK KCPPVWCDAE DPLFMLYTSG
     STGKPKGVLH TTGGYMLYAY TTFKYVFDYH DDDVFWCTAD IGWITGHSYV CYGPLVNGST
     SVIFEGVPYY PTAGRFWEIV EKYKVTKFYT APTAIRCLMK YGDEFVNNHD VSSLKVLGSV
     GEPINPEAWL WYHNVVGKGK CAVVDTFWQT ETGGHVLTPL PGATPTKPGS ATFPFFGVRP
     AILTAEGKEV KGPVEEGYLV FKQPWPGMMR TVYGNHERFE TTYFKKFPGF YCTGDGARRD
     EDDYIWITGR IDDMVNVSGH LISTAEVEAA IAEHSAVAEA AVVSHPHSVK GECTYGFVIL
     NDGFELTEKL ITELKCKVRT KIGPFAQPDY IQYAPGLPKT RSGKIMRRIL RKIAVGDTDF
     GDISTLADES VLELILKHRP QTIKA
//
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