ID A0A0L8HDH6_OCTBM Unreviewed; 1884 AA.
AC A0A0L8HDH6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Titin {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22017953mg {ECO:0000313|EMBL:KOF86825.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF86825.1};
RN [1] {ECO:0000313|EMBL:KOF86825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF86825.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF86825.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; KQ418560; KOF86825.1; -; Genomic_DNA.
DR EnsemblMetazoa; Ocbimv22017952m; Ocbimv22017952m.p; Ocbimv22017953m.g.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 36..68
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 69..101
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 102..134
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 135..158
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 197..229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 230..262
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 263..295
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 296..328
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 329..361
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 362..394
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 395..427
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 428..460
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 461..493
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 494..526
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 527..559
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 560..592
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 593..625
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 626..658
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 659..691
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 692..724
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 725..757
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1053..1218
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1220..1367
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1555..1638
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1690..1722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1835..1884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1850..1873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1884 AA; 206711 MW; 46552D7213E6A00F CRC64;
MSDGNSSFLR AARDGNLSEV LEYLKGSTDI NTSNSNGLNA LHLASKEGHI NIVTELLRRG
ANVEAATKKG NTALHIASLA GHEEIVKILV QNGAKVNVQS MTGFTPLYMA AQEGHSEVVK
FLLDNGASQS LATVDGFTPL AVALQQGHDK VVAVLLEHDT KGKVRLPALH IAAKKDDIGS
ANLLLQNDHN ADSSTKSGFT PLHIAAHYGN VNVGTLLIQK GADVNYKAKN NITPLHVASR
WGKSNMVILL LDHDATIEER TRDGLTPLHC AARSGHENVV DLLLERGAPF SAKTKNGLTP
LHMAAQGDHV DCARLLLYHK ALVDDVTVDY LTPLHVAAHC GNVKTAKLLL DRKSDPNARA
LNGFTPLHIA CKKNRIKVVE LLLKYDASIE ATTESGLTPL HVASFMGHMN ISIYLIQHNA
NPDYPTVRGE TALHLAARAN QTDIIRILLR NGATVDAKAR EQQTPLHIAA RLGNVDNVVL
LLQHGASPNA TTKDLYTPLH IAAKEGHEEV AAALLDQGAD HSLTTKKGFT PLHIAAKYGN
IKVARLLLLK NAEPDVQGKN GLTPLHVATH YNHVNVALLL LDNKASPQAM AKNGYSPLHI
AAKKNQMDIA TTLLEFGANP AAGSKNGFTP LHLASQEGHT DMVSLLLEHK ANVNDKATNG
LAPIHLAAQE DKVNVAEVLV KFGSEIDPQT KAGYTPLHTA CHFGQTNMVR FLLDHNASVS
STTKLGYTPL HQAAQQGHVM VINLLLKNKA SPNAVTNTGQ TALSIAQRLG YISVVDTLKN
LTEVTETLPA IEDKYKVVAP ETMTETMLSD SEDEGDDLMP QSPVFGKPLS EQHVYLPYYE
GQTLQMREDT ISIEKGDITS PLDLSFDKDL RKVRATSQEA RTRDISPGLA YPKYLEKGPD
YEAEMIYYSG DVLSPQEKKG DYFAEDIYAR ESFRYGREAG PVYRDTMISQ SVAPRTEAVV
YQGELTGSIA TDTGSDFRFL PDDSIPKQQD YLEHQIISHT YASHPDNRYL NNTMESSRYS
SYSGSSFNTS FDPDNVAVDR TPTYSGKLKW KSFLVSFMVD ARGGAMRGSR HSGVRIIIPP
RKAYMPTRVT CKLIKREKLS HPPPLNEGEA LASRILEMGP VGVKFLGPVI IEVPHFASLR
GKEREIAIIR CDDGEKWTEH PILATEEAVN DTLNGSFEGQ NSSASSLWKL DQEDELVAKR
ITRILTTDFP MYFAIVTRVR QENQTIGFEG GMLSSTVVPQ VQTIFPEGAL TKKIPVGLQA
QPIAPELVAK MLGNRVAVSP IVTVAPRRRK FHKPITLTIP VPRAAQKGMI NQYGGEAPTL
RLLCSISGGT TPAVWEDITA STQLTFVNDC VSFTTTVSAR FWLMDCQNVN EASRMATELY
QEAVVVPFMA KFVIFAKRHA PEEGKLRMFC MTDDKIDKTL EKQEKFTEVA RSRDVEVLQG
RPQYVEMAGN LIPVTKSGDQ LYVHFRAFRE NRLPCTVKVR DLDQEAAARV AFMKEPKVAR
GEAPQSPICN LNIVLPDVSK ADSTEITSEE ALEVRKRHSL LREHGIVLQD TISRAQMKIV
DVADTLQGDW VMLAQQLDIT MSEINKIKTD YNTVNDQALA MLHLWVEKNG EKASGNALEK
ALIRINREDV VKKCMYDVVT VEDEVDMAAG RVAMDQSGFD TFKEEVGISR DSSMKRGISL
DVSYDEQDMI KESESAEESG SDADTERHRI AKAPPPPAAM SQDEVLVKHV DHRRPEAAPV
AESSVDDTDR KKNAFVEFAR QMDELSDMEE TIKPVATSEQ DEKPSITEET IVSRVKGAGT
VTSVITKTVV TETVAKEAIV KDEAPEVMAP CVDVADSRSS SGSSICDKEQ QELVSHRTTE
LAQARDRLSE EMESNQHTPS ATGV
//
