ID A0A0L8HJN1_OCTBM Unreviewed; 623 AA.
AC A0A0L8HJN1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN ORFNames=OCBIM_22013090mg {ECO:0000313|EMBL:KOF89432.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF89432.1};
RN [1] {ECO:0000313|EMBL:KOF89432.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF89432.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF89432.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC ERF2/ZDHHC9 subfamily. {ECO:0000256|ARBA:ARBA00023463}.
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DR EMBL; KQ417980; KOF89432.1; -; Genomic_DNA.
DR RefSeq; XP_014771794.1; XM_014916308.1.
DR AlphaFoldDB; A0A0L8HJN1; -.
DR STRING; 37653.A0A0L8HJN1; -.
DR EnsemblMetazoa; Ocbimv22013090m; Ocbimv22013090m.p; Ocbimv22013090m.g.
DR EnsemblMetazoa; XM_014916308.1; XP_014771794.1; LOC106870287.
DR GeneID; 106870287; -.
DR KEGG; obi:106870287; -.
DR OrthoDB; 5480099at2759; -.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12349:SF2; PALMITOYLTRANSFERASE ZDHHC8; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 144..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 96..218
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 281..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 70778 MW; 8AEA5BB2F2ED167E CRC64;
MGRCEFSTRI LPATCAWSLL LVATGLFFIF IVPDHLEKYH MAIPIYQGIL SLFVVANFAL
ATFMDPGVYP KAHEDEFRDD DFRAPLYKNV EIKGITMRMK WCTTCQFYRP PRCSHCSVCN
NCIETFDHHC PWVNNCIGRR NYRYFFLFLI SLTIHKISIF SLCLLYVLDH KKELAQAGSI
VAFIVMVIIG ILIIPVAGLT GFHTVLVARG RTTNEQVTGK FRGSQNPFTR GCCKNCKYAL
CGPQWPRLVS YKPRTKTVQF ESSRVTYVAA DKDVKIFMDN SNGIKHDNTS NHRQASLSLD
EETERQSQSM DCEPSPPKQS GSYSNLFDPT NPTSVGAAMQ ANQGNHIGRI SPRIPPRNLY
TQSPQRTRSA DKKAPVATPE VVSPISSPTV KSQSSSPSPT KYNYAKPPIG YHTPRSNGFT
SLTPGPQMTM PSTGSSHPPY MGSSVNRGFS RTGSPVIYTL DKSKPQHCQY STGVGQPPYE
HGNNVNYSSP SHRYMPVEYS SVTYDPDKVR VPRRPMSFVR ALEVSEAVEQ KEKQHATPSK
RSEAYQEEEK PRNMRVNVAK RWKKHKKQKR IRKRNKDEKR IIYFRSNSNV DETVKRKIGK
FKNIKVLGMK TTRIKKMKRP DLR
//
