ID A0A0L8HMU1_OCTBM Unreviewed; 261 AA.
AC A0A0L8HMU1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Proliferating cell nuclear antigen {ECO:0000256|RuleBase:RU000641};
GN ORFNames=OCBIM_22011040mg {ECO:0000313|EMBL:KOF90522.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF90522.1};
RN [1] {ECO:0000313|EMBL:KOF90522.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF90522.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF90522.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is an auxiliary protein of DNA polymerase delta
CC and is involved in the control of eukaryotic DNA replication by
CC increasing the polymerase's processibility during elongation of the
CC leading strand. {ECO:0000256|RuleBase:RU000641}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000641}.
CC -!- SIMILARITY: Belongs to the PCNA family. {ECO:0000256|ARBA:ARBA00010462,
CC ECO:0000256|RuleBase:RU003671}.
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DR EMBL; KQ417740; KOF90522.1; -; Genomic_DNA.
DR RefSeq; XP_014771006.1; XM_014915520.1.
DR AlphaFoldDB; A0A0L8HMU1; -.
DR STRING; 37653.A0A0L8HMU1; -.
DR EnsemblMetazoa; Ocbimv22011040m; Ocbimv22011040m.p; Ocbimv22011040m.g.
DR EnsemblMetazoa; XM_014915520.1; XP_014771006.1; LOC106869688.
DR GeneID; 106869688; -.
DR KEGG; obi:106869688; -.
DR OMA; EMKLINM; -.
DR OrthoDB; 118939at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR CDD; cd00577; PCNA; 1.
DR Gene3D; 3.10.150.10; DNA Polymerase III, subunit A, domain 2; 2.
DR HAMAP; MF_00317; DNApol_clamp_arch; 1.
DR InterPro; IPR046938; DNA_clamp_sf.
DR InterPro; IPR000730; Pr_cel_nuc_antig.
DR InterPro; IPR022649; Pr_cel_nuc_antig_C.
DR InterPro; IPR022659; Pr_cel_nuc_antig_CS.
DR InterPro; IPR022648; Pr_cel_nuc_antig_N.
DR NCBIfam; TIGR00590; pcna; 1.
DR PANTHER; PTHR11352; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR PANTHER; PTHR11352:SF0; PROLIFERATING CELL NUCLEAR ANTIGEN; 1.
DR Pfam; PF02747; PCNA_C; 1.
DR Pfam; PF00705; PCNA_N; 1.
DR PRINTS; PR00339; PCNACYCLIN.
DR SUPFAM; SSF55979; DNA clamp; 2.
DR PROSITE; PS01251; PCNA_1; 1.
DR PROSITE; PS00293; PCNA_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU003671};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003671};
KW Nucleus {ECO:0000256|RuleBase:RU000641}.
FT DOMAIN 1..124
FT /note="Proliferating cell nuclear antigen PCNA N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00705"
FT DOMAIN 127..254
FT /note="Proliferating cell nuclear antigen PCNA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02747"
SQ SEQUENCE 261 AA; 28944 MW; 54EE623A5F9A1C61 CRC64;
MFEARLVQGS LLKKVLEAVK DLLSEAPWDC SSTGISLQAM DSSHVSLVSL LLRADGFDTY
RCDRNLSMGI NLNSMSKILK CACNDDIITV KAEDNADTVT FVFESPNQEK VSDYEIKLMD
IDSEHLGIPD TEYNCVVKLP SAEFQRICRD LSQIGDSVVI CCTKEGVKFS ASGDLGCGNI
KLAQSTNADK EEESVTIEMN QSVVLTFALR YLNFFTKATP LSTHVTLSMS QDVPLVVEYK
IADTGYIRYY LAPKIEDQED N
//
