ID A0A0L8HVU8_OCTBM Unreviewed; 620 AA.
AC A0A0L8HVU8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=OCBIM_22004714mg {ECO:0000313|EMBL:KOF93321.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF93321.1};
RN [1] {ECO:0000313|EMBL:KOF93321.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF93321.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF93321.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ417199; KOF93321.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8HVU8; -.
DR STRING; 37653.A0A0L8HVU8; -.
DR EnsemblMetazoa; Ocbimv22004714m; Ocbimv22004714m.p; Ocbimv22004714m.g.
DR EnsemblMetazoa; XM_014913492.1; XP_014768978.1; LOC106868303.
DR OMA; YSWELTN; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF548; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 426..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 478..617
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 620 AA; 72152 MW; 9762FD878B64B983 CRC64;
MVNISSLSLV SLKFENTAIY SSNSSAFENF RTLSILEFFG CYFQPRILYT AFANAKQLTK
LYITSTKIKE LSEYFFENLR WTQLTHLSLI RCGFDTFNGT QFSTLKYLRD LDFSENFIKT
TIWGINPSLN VLKIPHSSLQ HLPAFVSSRG ESYYPNLTRL EIGVERIPHL NETTCKGLQH
LQHLYIWCDQ LEKINSLFKP MQNLQTFHLC ASLFSHQPKL RITSSNFRSK TLQNLTLENV
RVFADTQIDL FRYFPSLISL QLIVTTLLSD SKSINQSLAF LPNLVTLQMS FSNLKTIPKV
ICNMVNLTSL NLKGNAIVWW NDTNCFVMKK LHFLSFSENR ISIVGDKTFS PLLINNKKLR
WDLSLNPFLC NCENAWFKSW VEKNHQKFLY YPKDFTCDTP ADLRGKQLSD IDLGNNICGV
SVMPSVGITI GIVLGSLMFV FVVVASISYY KRWALRYICY LLKSRKKQER SQQDEKSYVY
DAFICYHNSD SKYLLEKLQP KLEEENNFRL CIHDRDFVPG WDIVDNIVES IEKSHKIVLL
LSNNFALSEW CQFESTMAQQ RLFNEKKNTL IPILLEPIKI KNQTSRLTIL LKEKTYLEWT
DDKNGQKLFW ARLLNTMRGP
//
