ID   A0A0L8HVY0_OCTBM        Unreviewed;      1433 AA.
AC   A0A0L8HVY0;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=OCBIM_22004649mg {ECO:0000313|EMBL:KOF93357.1};
OS   Octopus bimaculoides (California two-spotted octopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX   NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF93357.1};
RN   [1] {ECO:0000313|EMBL:KOF93357.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF93357.1};
RC   TISSUE=Gonad {ECO:0000313|EMBL:KOF93357.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; KQ417193; KOF93357.1; -; Genomic_DNA.
DR   RefSeq; XP_014768952.1; XM_014913466.1.
DR   STRING; 37653.A0A0L8HVY0; -.
DR   EnsemblMetazoa; Ocbimv22004649m; Ocbimv22004649m.p; Ocbimv22004649m.g.
DR   EnsemblMetazoa; XM_014913466.1; XP_014768952.1; LOC106868277.
DR   OMA; ESDIGYR; -.
DR   OrthoDB; 927694at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 7.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24373:SF387; FISH-LIPS, ISOFORM E; 1.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00369; LRR_TYP; 15.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 4.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1178..1199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1227..1362
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          93..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1433 AA;  161580 MW;  B5D128A3554529B3 CRC64;
     MSSVKSSSQR ACVTMTSNSV SQISRCHSLR HLAVVAAATA TKHLEPKLNS HSTLNSAREE
     AMTPTKAKLT PISLSQFSTF LFIPPLLPFS SPFKPPPPAT PTQPLPLSSS SSSSSSSSSS
     SSSSSSSSSS SSSSSSSSSS SSSSSSSSHP PSPTLHCTSS SCSLSPSSNS VVGTTTFFSC
     PCSLPHYLPP PPSSPTTSRL SCSESLPPSL IKPLLPQPSP PPQSPISASS SLTSLSSSPA
     SVPFHWMIVL FLLLFSHSAQ PWVTQPEFQC PKQCECHNLR TSQLSTSIAA RCRINETMSR
     YNFSVFSAPY ITVLVIQCQG KPLKPVNKML RNLPFLEELV FKDCHFKSIP EYTLLGLNNL
     RNFSIFGADQ LTLTSNIFHK AVKLKNLEII HSGLKTIPVD MLCNSVDVEL LTLSQNELTH
     FSELKKLCQT NTTILDQITR LDLSYNLLQT IPADFSKLFS DMQMVNFVGN QIDNIEAGSV
     SDLYYLTVMD LSKNRIQSFP GDFLENSIGI QQLGISHNPI KTIFPYFKDL QDLEVFEAEH
     TYLDNSFFRE IPKGSALTNL NLAHCYMSKI NKSLMSNLKN LRRLNLNSNS IFSLPSNVFS
     SNDKLDVLIL SNNNIEELLD NSLQGLRALR ELDISYNNIS VINEDAFHDL LVIEKLDLSF
     NQLYDIPNAI TPLDKIQELY LEGNFISKIN KNSFKGLDSI NRIVLSKNRI VFLDASSFTR
     CFNLHILDLS ENNISYIHED AFEGLQLVGV SLANNKIRNI GTALWKQHNL SQVHLQGNLL
     EAIMSSNFPE NVKFLNVSHN RIWNVHPFTF SNKDTLVEVD LRHNNISFLA NDAISVSHRV
     RSIPDVYLMG NPFKCDCNIV WLKKLANVRP RKKDGLPYIP DLNELECHAD NESSVPTGRM
     YEVKESDFLC KYLKECAPDC ICCTFGMCDC NSICPEQCSC YRSYDRKANI INCMNSGLSD
     SRMLPSNATK IYLSGNRLIS LSKHSFLRQR DLLTVLYLNR SHISNIQNGT FMTLINLKQL
     YMHDNDLTIL TKETFQGLEN LEVITLNSNS ISYIAPGMFA PMPKLKIVDV SSNRLHILDN
     SFLSLKYLES IAIHNNPWIC KCPFVMGLQE LYINKPDLVV LSESVICDHE DVINSSMSFY
     TAYPLFEFDV QLHCLNITPV TNLSSHVNTQ IDSKVICALA IFSAVFLTLI IAVISIACYR
     EELKVWLFTQ YGWRIGDPWA KLDDSNRRYD VFVAYTSKNA MFVEHELTPR LERREPPYQV
     CLTYRDYDVD ISYAQNTINC IQNSKRTIML VSNDFFQTEW FRYDFQINNH DILKTLSERL
     IVILMEKVDR KKLECDLMFY AKTKKFLKYQ DTHFWDKLYY MLPKVRGLPL LPQTPESAVS
     SGELRDQCCN NIAFSKTSLE SGYEEINFVR KNVFPRSDHQ TVYLAPVCQR NCK
//