ID A0A0L8HYA8_OCTBM Unreviewed; 466 AA.
AC A0A0L8HYA8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Complex I-49kD {ECO:0000256|ARBA:ARBA00030505};
DE AltName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit {ECO:0000256|ARBA:ARBA00031562};
GN ORFNames=OCBIM_22002646mg {ECO:0000313|EMBL:KOF94166.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF94166.1};
RN [1] {ECO:0000313|EMBL:KOF94166.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF94166.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF94166.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00005769, ECO:0000256|RuleBase:RU003685}.
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DR EMBL; KQ417023; KOF94166.1; -; Genomic_DNA.
DR RefSeq; XP_014768428.1; XM_014912942.1.
DR AlphaFoldDB; A0A0L8HYA8; -.
DR STRING; 37653.A0A0L8HYA8; -.
DR EnsemblMetazoa; Ocbimv22002646m; Ocbimv22002646m.p; Ocbimv22002646m.g.
DR EnsemblMetazoa; XM_014912942.1; XP_014768428.1; LOC106867881.
DR GeneID; 106867881; -.
DR KEGG; obi:106867881; -.
DR OMA; IMGTSME; -.
DR OrthoDB; 191at2759; -.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR HAMAP; MF_01358; NDH1_NuoD; 1.
DR InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR InterPro; IPR014029; NADH_UbQ_OxRdtase_49kDa_CS.
DR InterPro; IPR022885; NDH1_su_D/H.
DR InterPro; IPR029014; NiFe-Hase_large.
DR NCBIfam; TIGR01962; NuoD; 1.
DR PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR Pfam; PF00346; Complex1_49kDa; 1.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR PROSITE; PS00535; COMPLEX1_49K; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003685};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003685};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003685}.
FT DOMAIN 196..466
FT /note="NADH-quinone oxidoreductase subunit D"
FT /evidence="ECO:0000259|Pfam:PF00346"
SQ SEQUENCE 466 AA; 52719 MW; 5A73205B90431C4B CRC64;
MAVIGGLLRA TVPNILSLSK KNILGYAPTL FVSSRGANKW LLDSEYLGKM TGPIMYPDEI
SSKWKNLPVN PRGEVKEKEV QNVTMNFGPQ HPAAHGVLRL VLTLDGETIE RADPHIGLLH
RGTEKLIEYK TYMQALPYFD RLDYVSMMCN EQCYSLAVEN LLNIEIPERA KWIRTLFGEI
TRILNHIMAV GTHALDIGAM TPFFWLFEER EKMMEFYERV SGARMHAAYV RPGGVSQDLP
LGLMDDIFDF ISKFGERLDE VDALLTENRI WKSRTVDIGI ISAEDALNYG CSGVMLRGSG
IKWDLRKVQP YDAYDKVDFD IPIGRKGDCY DRYLIRMEEM RQSLNIIHQC LNKMPPGEIK
VDDHKICPPK RSEMKSSMES LIHHFKLYTE GYNVPPGSTY TAVEAPKGEF GVYLVSDGSN
KPYRCKIKAP GFAHLAALDK VSKKHMLADV VAIIGTLDVV FGEVDR
//
