ID A0A0L8I6G4_OCTBM Unreviewed; 148 AA.
AC A0A0L8I6G4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=MD-2-related lipid-recognition domain-containing protein {ECO:0000259|SMART:SM00737};
GN ORFNames=OCBIM_22034232mg {ECO:0000313|EMBL:KOF96610.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF96610.1};
RN [1] {ECO:0000313|EMBL:KOF96610.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF96610.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF96610.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NPC2 family.
CC {ECO:0000256|ARBA:ARBA00006370}.
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DR EMBL; KQ416526; KOF96610.1; -; Genomic_DNA.
DR RefSeq; XP_014790765.1; XM_014935279.1.
DR AlphaFoldDB; A0A0L8I6G4; -.
DR STRING; 37653.A0A0L8I6G4; -.
DR EnsemblMetazoa; Ocbimv22034232m; Ocbimv22034232m.p; Ocbimv22034232m.g.
DR EnsemblMetazoa; XM_014935279.1; XP_014790765.1; LOC106884063.
DR GeneID; 106884063; -.
DR KEGG; obi:106884063; -.
DR OMA; VDIKWEL; -.
DR OrthoDB; 2545683at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032367; P:intracellular cholesterol transport; IEA:InterPro.
DR CDD; cd00916; Npc2_like; 1.
DR Gene3D; 2.60.40.770; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR033916; ML_Npc2-like.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR PANTHER; PTHR11306:SF73; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..148
FT /note="MD-2-related lipid-recognition domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005584192"
FT DOMAIN 24..145
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
SQ SEQUENCE 148 AA; 16024 MW; CC1CEA2D37AF5829 CRC64;
MNNSLYFTPL FFLAFAFVVS ASPYLACQSE LGTVSDVRVS NCDSSPCILP RGGQVTIEID
FTLNSDVHTA LDSVFGIISG MHVPFPTTSP NACSGKGLTC PLKQGVKYTY KSVIPISAIF
PKLRLIVEWS VVEGTKKLFC VKIPALLQ
//
