ID A0A0L8IEC7_OCTBM Unreviewed; 1162 AA.
AC A0A0L8IEC7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=OCBIM_22011966mg {ECO:0000313|EMBL:KOF99764.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF99764.1};
RN [1] {ECO:0000313|EMBL:KOF99764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF99764.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF99764.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KQ415895; KOF99764.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L8IEC7; -.
DR STRING; 37653.A0A0L8IEC7; -.
DR EnsemblMetazoa; Ocbimv22011966m; Ocbimv22011966m.p; Ocbimv22011966m.g.
DR OMA; WTQDRDP; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 4: Predicted;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 338..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 344..510
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 615..906
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 920..1109
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1162 AA; 127816 MW; 67E7CB53CE016F30 CRC64;
MNDIDAQYNV VVLLLDIVKD VADIKVNKIV FSNVPINKQS LVYNIRGKMS GRIDSMETLL
VVAEKGKKYK LIKEITEKAT SETRVHMRAH THTYTHIRIN EVDTSNILKL IQCSTSYISK
EKSFVLVPHS KEAVIIISEV RESSSLVAVA AAASSLSSSA AATMSSLSSS SSSSSSPPAT
SSLLSSSYVC FPCCCHKVFV FTFQLRNKFH FIENFLHLDA LPNDNHSKSV MGAICDDYDF
TWLDGSSTQT QHNAEGLAHS LCEVQYSKGE NTQNREHEPL TDNNDDIGHH QLALYEEDLQ
RRGKVSNIIN RIGNYQAGIA PNLEEEEAAP KKSKGAKLGT LMGVYLPCIQ NIFGVLLFVR
MTWIVGSAGA IESFLIVIVC CSTTLLTSIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA
VGILFYLGTS VASSMYIIGA VEILLTYIAP QMSIFDDMYH NFRIYGTATL ILLSTFVFIG
VRFVSKFATL SLACVILSII SIYIGIFVTN ENRSIKICIM GDRLLTLESV TANGSIWCDK
NISGPIYAHY CGDGNTSDSC NYFFANQVRY VPGIPGIASG LFETNAFSKY SKINDVPGSS
DAGDAARGEI IADITTTFMV LLAIYFPSVT GIMAGSNRSG DLADAQKSIP TGTVAAIMTT
SLHGKRTLND DDDDDDDITS VFFFAACVEG PLLRDKFGES INGGLVVANL AWPNEWVILI
GSFLSTLGAG LQSLTGAPRV LQAIAKDSVI PLLDIFSVTT KKGEPFRALL LTAAISEIGI
IIASLDYVAP IITMFFLLCY GFVNMACALQ TLLRTPNWRP RFRFYHWTLS LLGLGLCISL
MFISSWYYAL AALFLALCIY KYIEYKGAEK EWGDGIRGLA MSAARYALLR LQEGPPHTKN
WRPQLLVLMK PDENLKPMYP KLATLATQLK AGKGLILVSS VLEGDFRKTF AKSQAAKQAL
DHLMDTENIK GFADVLVAKS VIEGLCHLTQ TAGLGGLKHN TIMIGWPYGW RHSPEQKSYR
VFIELEDNSI QMEKDLNQYM YNLRIEAEVK IVEMSNSDIS AYTYERTLMM EQRTELLSNM
RLQKETAQSI IDRAHNPTSL ESKDATLETV VEEAIEFNDA ANSLELDRSQ YTFSPSEAKS
LGKELGKELF QMKPLVSNYS IC
//