ID A0A0L8IFR5_OCTBM Unreviewed; 4450 AA.
AC A0A0L8IFR5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=OCBIM_22010370mg {ECO:0000313|EMBL:KOF99855.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOF99855.1};
RN [1] {ECO:0000313|EMBL:KOF99855.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOF99855.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOF99855.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ415876; KOF99855.1; -; Genomic_DNA.
DR STRING; 37653.A0A0L8IFR5; -.
DR EnsemblMetazoa; Ocbimv22010370m; Ocbimv22010370m.p; Ocbimv22010370m.g.
DR OMA; QRENMAG; -.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1848..1984
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2433..2578
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 375..402
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1233..1260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3020..3106
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3251..3299
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4450 AA; 511717 MW; 38C7EF265C068741 CRC64;
MITTGASELT DLTDPRVFFV ADYVLKTFGL KGEKWSKMYS IEENKIMMNE FFEKTEMSTL
IFILNSAGAL QMQQNWPEAP NGKSCYFVRR NKEPISRETA LRTALLYGDL SYSPLEHLSV
FVDEILVPIL TNEKNHEHWP RVVSQDIIRQ VHNLKRNVDV VIGQVKGKTL LPLPVGIENI
DNLDIKDSLL TRALVHSTES VVIEWSHQIQ DVLKRHSAQF LKDGQNPTPF VELNFWQDRL
KNLNCIYDQL QAPRVVKMAS LLERTNSVYH ISFQNLLQDV VSALDEARDI NIFLKPLHNL
FTDIQQADFT DLTEHFPPLI HVICLIWANS NFYNTAPRIT VLLQETCNLV INLARDHSEP
TEIFKGEIEE SMVKVRNVEQ ILECFKDTYE EYKSKLEEYF SDQTQVKLWQ FSPALVFDRF
DKFQQRIQVV KKLMETSTEF MKLEKVELGG IKGKILSKQV IQISDEFKEQ YKVFQEKTYD
TLDSNNQEFL DDYEKFQNRI YDLDRRLGTI ICQGFDDCSG LQSCFKLIDM MGSLLERPLI
KKDFNGKYLK IVDMLNEELD TAKEMYNEQM VLLKETGCIM VHKFMPKVSG CLKWAQELQE
RITSSVGSFK HLDHSCTTNE EAILIYRKYE EMMNLLSNFE QEQYTEWAKT VDDACCFNLS
QPLLSRNEQT NLISVNFDAQ LIAVLKEVKY MEIRGMENIP TSSNELYARR DDIFQYVTNL
DMIVLWYNNI RTSIIEVEFP LIEKQIDDID HKLKNAEKVM NWNSSGIWEY IEETKNMVYD
LESRLHNSKD NVQKIEQLMA TWSKTPLFER KEDKFGSLLN LDDRGERLRK RYKEIEDAGD
QIHKLLQENV DYFKADPNSE VWKAYVDYVD DIVVDGFFRT VDTSLTFLLE NTESNSTHEP
LFQAQLELCK PDMVFSPSLD YGTADGFYDL VDGVVGSIYK QATLILRLAK HSDQVNYQPD
LEEMDELNDK RNELMERVQN VMNKACEYRN SFDTYAYLWV DDRNEFMRQF LLYNHVLTTE
EIEAHAEDGV PECPPTLEQF KEQIDTYEKI YDVAETIQKT SVFESWFRVD ASPFKQALLN
IIKRWSYMFK QHLIDHVTNS LADLSEFIKS ANEGLTKTVE EGDYNGLVTI MGNLGAVRER
LAATDEMFEP LKQTIELLKI YNQEMPEEVH IQLEELPERW NNTKKIAITV KQQVAPLQAA
EVNNIRRKTA AFDVKQHKFR EAFHQISPFF YTCQNAYEHL DKYHEEIHKM EMEMTNLQAS
ASLFEVSIPD FKQLKQCRKE LCLLKHLWDY ITVIQSSIDN WKTTLWLDID VDQMDIDCKL
FSKDIRQLDK EMRAWDVYSG AESTVKNMLT SLRAVGELQN KAIRDRHWQQ LMQATNVRFV
MDDTCTLADL LLLNLHNYEE EAKTIVDKAV KEMSMEKVLG DLDETWGAME FDHDKHASTN
TTLLRASEEL IETLEENQVQ LQNMLTSKFI DYFRSEVTSW QMKLSTADQV ISIWMEVQRT
WSHLESIFIG SEDIRKQLPK DSERFDNIDS DFKQIVSEVE VTKNVIQATS CPNLYERLEK
IQSELVKCEK ALAEYLETKR LAFPRFYFVS PVDLLDILSN GNNPTAVCTH LTKLFDSLAK
LEFEKDSDGN DTKIATGMYS KDGEYVALDH KCDCSGQVEV WLNSVLDTMR STIRYQMTEA
VVGYEEKARD LWLFDYCAQV ALCGTQIWWT TDVNMAFGRL EEGYENAMKD YNKKQIQQLN
ALITMLVGEL NKGDRQKIMT ICTIDVHARD VVTKMIANKV DNAQAFSWLS QLRHRWDEQG
LKDCFANICD AQFRYSHEYL GNAPRLVITP LTDRCYITLT QSLHLIMSGA PAGPAGTGKT
ETTKDLGRAL GVMVYVFNCS EQMDYKSVGN IYKGLAQSGA WGCFDEFNRI SVEVLSVVAV
QVKSIQDAIK DKKKEFNFMG EHIKIVPTVG IFITMNPGYA GRTELPENLK ALFRPCAMVV
PDFELICEIM LVAEGFLDAR LLARKFITLY QLCKELLSKQ DHYDWGLRAI KSVLVVAGSL
KRSDPNRAED QVLMRALRDF NIPKIVTDDL PVFMGLISDL FPSLDVPRKR DMVFEKNIRQ
AVLDKQLQPE DSFILKVVQL QELFDVRHSV FIIGNAGTGK SQVWNVLLQT HRNQKLKPLA
IVLDPKAVTN DELFGIINPS TREWKDGLFS VIMRDLSNMS GDGLKWIVLD GDIDPMWIES
LNTVMDDNKV LTLASNERIP LTPSMRLLFE ISHLKTATPA TVSRAGILYI NPQDLGWNPY
VQSWIDRREI QSEKANLTIL FDKYVPTCLE TLRQRFKKIT PIAECSHIQM LCYLLECLLC
PENTPADSPK ELYELYFVFA CIWAFGGAMF QDQLVDYRNE FTKWWINEFK SVKFPSQGTV
FDYYIDPETK KFEHWSKPET TRIRYFLDIL IASKRPVMLV GTAGSGKTVL MQDKLISLPD
EYVIANVPFN FYTTSEMLQR ILEKPLEKKA GRNYGPLGNK KLIYFVDDMN MPEVDQYFTV
QPHTLMRQHL DHNQWYDRVK LTVKDIHNTQ YVACMNPTAG SFTIDPRLQR HFCVFAINFP
SQDALNTIYC SILSQHLIFN NFAPQVQKFS PNIITAALTL HQRVSSNFLP TAIKFHYVFN
LRDLSNIFQG ILFSSPECCK TPTDLIRLWT HESQRVYCDK LIDAKDIVNY LKLEKDVIKK
SFEDIDESAL TKKPLLYCHF TQGIGDAKYL PVSDWNSISA ILKETLDSYN ELNAVMNLVL
FEDAMTHICR INRILESPRG NALLIGVGGS GKQSLSRLAA YISSLEVFQI VLRRGYGIPD
LKMDLNIQYQ KAGLKNIGTV FLLTDAQVAD EKFLVLINDL LASGEIADLF ADDEVETIIS
TVRSEVKAQG LEDTRENCWR YYIDKVRRSL KVVLCFSPVG PTLRIRSRKF PAITNCTSID
WFHEWPEEAL VSVSQRFLEE VELLAPPMRE AISKFMAFVH KSVNDTSDLY LQNERRYNYT
TPKSFLEQIK LYQNLLNKNN TNLQAQIVRL ENGLEKLRNT SSQVDDLKAK LAAQEVELAQ
KEEDANKLIA IVGAETEKVS KEKRIADEEE KKVQKINEEV SKKAQDCEED LTKAEPALIA
AKKALDTLNK SNLTEMKSFG APPSAVTNVT AAVMVLLAPG GKIPKDRSWK AAKSTIMSKV
DTLLVQLKEY DKENIHENCR KAIQAYLTDK EFNPELISAK SSAAAGLCAW VINIMKFYEV
FCEVEPKRIA LNQANAELAA AQDKLAVIQN KITELEKSLA KLTNEFEEAT NAKMKCQAEA
DATNKTIVLA NRLVGGLASE NVRWAESIRG LKKQEITLPG DTLLITSFVS YLGCFTKSYR
LDLINKHWTN YLNSVKEIIP ISEGLDPLTL LTDDASIAEW NNEGLPSDRM SIENATILTN
CERWPLMVDP QLQGIKWIKK RFSSTLKVVR IGQKGYLEII EKAISTGETV LIENLGESID
PVLDPLLGRN TIKKGRAIRM GDKEVEYNSS FQLILHTKLA NPHYKPEMQA QTTLINFTVT
RDGLEEQLLA AVVSKERPDL ERLKSDLTHQ QNEFKITLKK LEDSLLARLS AAEGNFLGDY
ALVENLETTK RTAAEIEVKV VEAKKTEKEI NLARESYRPA AERASLLYFQ LNELSKINPM
YQFSLKAFSV VFEKAIERAE PADDVKQRVV NLIDSITYSV FIYTTRGLFE KDKLIFTCQM
AFQILLLKKE INATELDFLL RFPSIPNLTS PVDFINNLGW GGIKALASLE DFRNLDRDIE
GSAKRWKKFV ECESPEKEKF PQEWKNKTSL QKLCMMRALR PDRMTYAIRN FIEEKMGTQY
VEGRQVDFAK SYEESGPGTP VFFILSPGVD PLKDVEALGK KLGFSNDNKN FHNISLGQGQ
EIIAEEAMDI SAQDGHWVIL QNVHLVAKWL ANLEKKLEEY SVDSHESYRV FISAEPAASA
ASHTIPQGIL ESAIKITNEP PTGMQANLHK ALDNFDQDTL EKCAREVEFK SILFALCYFH
AVVQERRKFG PQGWNRIYPF NVGDLTISVN VLYNYLEANN KVPWEDLRYL FGEIMYGGHI
TDDWDRRLCI TYLEVYMHPD MLDTELYLAP GFPIPPNIDY KGYHTYIDEM IPTESPYLYG
LHPNAEIEFL TSTSEHLFRT VFEMQPRDAG SDSEAGVSRE EKVKSILDEI IEKLPEEFIM
AEIMAKVPLE ERTPYVVVAF QECERMNLLT SEIRRTLKEL DLGLKGELTI TSDMEELSNS
LFMDQVPGNW AKRAYPSLYN LTTWYADLLQ RVKELESWVT DFQLPAAVWL AGFFNPQSFL
TAIMQQMARK SEWPLDKMCL QCDVTKKMRD DMAGPPREGA YIHGLFMEGA RWDMQSGMIA
ESRLKDLTPV MPVIFIKAIP VDRQDTKTIY QCPVYKTKQR GPTFVWTFNL KSKEKSSKWI
LGGVALLLQV
//
