ID A0A0L8IH46_OCTBM Unreviewed; 382 AA.
AC A0A0L8IH46;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN ORFNames=OCBIM_22005137mg {ECO:0000313|EMBL:KOG00339.1};
OS Octopus bimaculoides (California two-spotted octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=37653 {ECO:0000313|EMBL:KOG00339.1};
RN [1] {ECO:0000313|EMBL:KOG00339.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UCB-OBI-ISO-001 {ECO:0000313|EMBL:KOG00339.1};
RC TISSUE=Gonad {ECO:0000313|EMBL:KOG00339.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR EMBL; KQ415813; KOG00339.1; -; Genomic_DNA.
DR RefSeq; XP_014769011.1; XM_014913525.1.
DR AlphaFoldDB; A0A0L8IH46; -.
DR EnsemblMetazoa; Ocbimv22005137m; Ocbimv22005137m.p; Ocbimv22005137m.g.
DR EnsemblMetazoa; XM_014913525.1; XP_014769011.1; LOC106868326.
DR GeneID; 106868326; -.
DR KEGG; obi:106868326; -.
DR OMA; SVEAHIN; -.
DR OrthoDB; 6683at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR12246; PALMITOYLTRANSFERASE ZDHHC16; 1.
DR PANTHER; PTHR12246:SF13; PALMITOYLTRANSFERASE ZDHHC16; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 267..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 138..306
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
SQ SEQUENCE 382 AA; 44969 MW; 226BA18D2B8C5972 CRC64;
MKILRWRINI CQWASNLRFS LNTTCDLIKL MYFSLCYNAF TSPSLILETG LEPVFWIVDH
FAKYMGPILM FIVFALCSIG LVIFYVIMIP RYLSYGWHWF LPNFIFGNWL LVNTVFNYVM
GCRTNPGHPP QIVPEVVSIC KRCISPKPPR AHHCSVCKKC VLRMDHHCPW LNNCVGFYNH
RYFFLYMVYM MSGCLYACFL FYPLFYDNFY VGKEVVFHGV LYPLNMAYQF WMSKNKSYTY
IAISNGTSVK RTPPPQSFNQ LTLSDQIYHH SVIFVFFLGF GCVIALSILS LWHARLVSRG
ETSIEVHINK NERKRLKKLG QTYVNPYDFG FVQNWKLFFG LTEGRTFWRH ILFPSRHKPP
GNGLQWKTTT FTVDNFENIH VL
//
