ID A0A0L8KTN6_9ACTN Unreviewed; 683 AA.
AC A0A0L8KTN6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=phospholipase C {ECO:0000256|ARBA:ARBA00012018};
DE EC=3.1.4.3 {ECO:0000256|ARBA:ARBA00012018};
GN ORFNames=ADK37_36505 {ECO:0000313|EMBL:KOG29225.1}, AQJ84_03705
GN {ECO:0000313|EMBL:KUO01556.1};
OS Streptomyces resistomycificus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=67356 {ECO:0000313|EMBL:KOG29225.1, ECO:0000313|Proteomes:UP000037251};
RN [1] {ECO:0000313|EMBL:KOG29225.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 2290 {ECO:0000313|EMBL:KOG29225.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000037251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2290 {ECO:0000313|Proteomes:UP000037251};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KUO01556.1, ECO:0000313|Proteomes:UP000052992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40133 {ECO:0000313|EMBL:KUO01556.1,
RC ECO:0000313|Proteomes:UP000052992};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces resistomycificus DSM 40133, type
RT strain for the species Streptomyces resistomycificus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:10604,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:295975; EC=3.1.4.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10605;
CC Evidence={ECO:0000256|ARBA:ARBA00023550};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the bacterial phospholipase C family.
CC {ECO:0000256|ARBA:ARBA00009717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOG29225.1}.
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DR EMBL; LGUS01000222; KOG29225.1; -; Genomic_DNA.
DR EMBL; LMWZ01000002; KUO01556.1; -; Genomic_DNA.
DR RefSeq; WP_030042045.1; NZ_LGUS01000222.1.
DR AlphaFoldDB; A0A0L8KTN6; -.
DR STRING; 67356.AQJ84_03705; -.
DR PATRIC; fig|67356.5.peg.7809; -.
DR eggNOG; COG3511; Bacteria.
DR OrthoDB; 4181857at2; -.
DR Proteomes; UP000037251; Unassembled WGS sequence.
DR Proteomes; UP000052992; Unassembled WGS sequence.
DR GO; GO:0034480; F:phosphatidylcholine phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR CDD; cd16014; PLC; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR017767; Bact_PC-PLC.
DR InterPro; IPR007312; Phosphoesterase.
DR InterPro; IPR008475; PLipase_C_C.
DR InterPro; IPR006311; TAT_signal.
DR NCBIfam; TIGR03396; PC_PLC; 1.
DR PANTHER; PTHR31956:SF8; ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570); 1.
DR PANTHER; PTHR31956; NON-SPECIFIC PHOSPHOLIPASE C4-RELATED; 1.
DR Pfam; PF04185; Phosphoesterase; 1.
DR Pfam; PF05506; PLipase_C_C; 2.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Reference proteome {ECO:0000313|Proteomes:UP000037251};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 496..582
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT DOMAIN 598..667
FT /note="Bacterial phospholipase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05506"
FT REGION 452..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 75068 MW; D3D7D00D9C298DBC CRC64;
MPEVNRRRFL QIAGATTAFT ALSASIERAA AIPANHRTGS IEDVEHVVVL MQENRSFDHY
FGKLRGVRGF GDPHPVTLPS GRSVWHQSDG TRELLPFHPT ADDLGMQFLE GLPHSWPDGQ
QAYNGGAYDQ WVPAKGTTTM AYLTREDIPF HYALADKFTI CDAYHCSFIG STDPNRYYMW
SGYTGNDGTG GGPVLGNDEL GYGWTTYPER LEKAGISWKI YQDIGDGLDA QGSWGWIQDA
YRGNYGDNSL LYFDSYRDAQ PGDPLHEKAR TGTDVKNGDG YFDRLKADVK AGKLPQISWI
AAPEAFSEHS NWPSNYGAWY ISQVLDALTS NPAVWAKTAL FITYDENDGF FDHLVPPLPP
RSDAQGRSTV DVGPDLFKGG DTHVAGAYGL GPRVPMLVVS PWSKGGYVCS ETMDHTSILR
FMERRFGVRE PNISPWRRAI CGDLTSAFDF SREDTGPVAL PDTDDYEPPD RERHPDYRPT
PPARGALPRQ ERGLRPARPL KYAPHVDGSV DAPAGKLTLT FASGAKAGAA FLVTSGNRGD
GPWTYTTEAG KTIADTWNSA YSNGSYDLTV HGPNGFLRVF RGPNKAAGPE VTARHRGDDV
ELTFTNRGSG TARLKVRSGY GDRARSFTVR AGATVRHTFD LKASRRWYDL TVTSEADPAF
LRRFAGHVEN GRPGVSDPAV MTG
//
