ID   A0A0L8L5L1_9ACTN        Unreviewed;       515 AA.
AC   A0A0L8L5L1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Proteinase {ECO:0000313|EMBL:KOG33498.1};
GN   ORFNames=ADK37_22720 {ECO:0000313|EMBL:KOG33498.1}, AQJ84_08375
GN   {ECO:0000313|EMBL:KUO01035.1};
OS   Streptomyces resistomycificus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX   NCBI_TaxID=67356 {ECO:0000313|EMBL:KOG33498.1, ECO:0000313|Proteomes:UP000037251};
RN   [1] {ECO:0000313|EMBL:KOG33498.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL 2290 {ECO:0000313|EMBL:KOG33498.1};
RA   Tran T., Druce J.;
RT   "MeaNS - Measles Nucleotide Surveillance Program.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000037251}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 2290 {ECO:0000313|Proteomes:UP000037251};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KUO01035.1, ECO:0000313|Proteomes:UP000052992}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40133 {ECO:0000313|EMBL:KUO01035.1,
RC   ECO:0000313|Proteomes:UP000052992};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces resistomycificus DSM 40133, type
RT   strain for the species Streptomyces resistomycificus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family.
CC       {ECO:0000256|ARBA:ARBA00010088}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOG33498.1}.
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DR   EMBL; LGUS01000173; KOG33498.1; -; Genomic_DNA.
DR   EMBL; LMWZ01000003; KUO01035.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L8L5L1; -.
DR   STRING; 67356.AQJ84_08375; -.
DR   PATRIC; fig|67356.5.peg.4838; -.
DR   eggNOG; COG0596; Bacteria.
DR   Proteomes; UP000037251; Unassembled WGS sequence.
DR   Proteomes; UP000052992; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR013595; Pept_S33_TAP-like_C.
DR   PANTHER; PTHR43248; 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE; 1.
DR   PANTHER; PTHR43248:SF29; AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   Pfam; PF08386; Abhydrolase_4; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037251};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..515
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011858817"
FT   DOMAIN          85..238
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
FT   DOMAIN          386..482
FT                   /note="Peptidase S33 tripeptidyl aminopeptidase-like C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08386"
FT   REGION          20..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  56104 MW;  40108CB7A3D87B50 CRC64;
     MAVGALVTAL FGQLLAGTAA AAPPDRTPSP GRIAWEPCQS PSGEGSFECA SIKVPVDWRR
     PRGATIDLAL ARHLATDPDR RIGSLLINPG GPGGSGVDFA LTAPESFSPQ LLERFDIVGF
     DPRGVGRSNP VKCDADRVAD QGALLYPDSA SSFAALREAN HALGENCRDL TGPLVDNMDT
     TSVIRDMETI RAGLGEKRIS YYGVSYGTGI GQQYAERYPH RVRAMTLDSN MDHSLNPWTY
     QKTETIAMEE SYGQFADWCA RTASCVLHDR DGRALFDSLY RRAAAGELVL PGDPPYTFTT
     QDLQGLAFGY MYDPASWFQF AEELAYLDAP DAASGRLVGK RGEPTEFGYL PVMCQDYDFD
     LPSYRTLARF ERGLARLAPV TRLSSLAWSD LTGCQNWPTE VTNPPHRLHV DGTPRILVTN
     SRYDVATPHS WGSNAARQIG HEAVFLTYDG VGHGDYWLSP CARDAIDTYL ITLKTPRRGT
     HCPAVWPTGP SAQRQSPSGG LVNPLPDLLG TGTRR
//