ID A0A0L8LKA6_9ACTN Unreviewed; 1737 AA.
AC A0A0L8LKA6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Hydrolase {ECO:0000313|EMBL:KOG38567.1};
GN ORFNames=ADK37_09590 {ECO:0000313|EMBL:KOG38567.1}, AQJ84_06190
GN {ECO:0000313|EMBL:KUO00595.1};
OS Streptomyces resistomycificus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=67356 {ECO:0000313|EMBL:KOG38567.1, ECO:0000313|Proteomes:UP000037251};
RN [1] {ECO:0000313|EMBL:KOG38567.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 2290 {ECO:0000313|EMBL:KOG38567.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000037251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2290 {ECO:0000313|Proteomes:UP000037251};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KUO00595.1, ECO:0000313|Proteomes:UP000052992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40133 {ECO:0000313|EMBL:KUO00595.1,
RC ECO:0000313|Proteomes:UP000052992};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces resistomycificus DSM 40133, type
RT strain for the species Streptomyces resistomycificus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOG38567.1}.
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DR EMBL; LGUS01000083; KOG38567.1; -; Genomic_DNA.
DR EMBL; LMWZ01000003; KUO00595.1; -; Genomic_DNA.
DR RefSeq; WP_053190767.1; NZ_LGUS01000083.1.
DR STRING; 67356.AQJ84_06190; -.
DR PATRIC; fig|67356.5.peg.2079; -.
DR eggNOG; COG3507; Bacteria.
DR eggNOG; COG5492; Bacteria.
DR OrthoDB; 9758923at2; -.
DR Proteomes; UP000037251; Unassembled WGS sequence.
DR Proteomes; UP000052992; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd08983; GH43_Bt3655-like; 1.
DR CDD; cd09004; GH43_bXyl-like; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 2.60.40.2340; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR046780; aBig_2.
DR InterPro; IPR011081; Big_4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR43772:SF2; BETA-1,4-XYLOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR43772; ENDO-1,4-BETA-XYLANASE; 1.
DR Pfam; PF20578; aBig_2; 2.
DR Pfam; PF07532; Big_4; 1.
DR Pfam; PF04616; Glyco_hydro_43; 2.
DR Pfam; PF13385; Laminin_G_3; 2.
DR Pfam; PF18911; PKD_4; 1.
DR SMART; SM00560; LamGL; 2.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF49299; PKD domain; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KOG38567.1};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00022651};
KW Reference proteome {ECO:0000313|Proteomes:UP000037251};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Xylan degradation {ECO:0000256|ARBA:ARBA00022651}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..1737
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011859012"
FT DOMAIN 110..252
FT /note="LamG-like jellyroll fold"
FT /evidence="ECO:0000259|SMART:SM00560"
FT DOMAIN 909..1051
FT /note="LamG-like jellyroll fold"
FT /evidence="ECO:0000259|SMART:SM00560"
FT REGION 292..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1155
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 1314
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 1267
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 1737 AA; 184045 MW; 3B7976AB7CA2AC52 CRC64;
MTYRARLRGR ARRLTGRLAG LTAASLLLGL GPAVPAQAAE TADTAEITDG LALWYPLDAA
SGTAATDASG NGRTGTVNGT AGWSASGQGL AFNGSDTYIK VPDDVMKGMN AISVSMDVLI
DSAQTTPYFI YGFGNTSAGN GNGYLFTTGN SLRTSIATGN WSTEQTTKPG DSHNLARAAW
KHLTYTQTGT TGVLYEDGVE VGRNTAVTTT PGAIGSGTTT ANYIGKSVYS GDKLFKGRIR
DFRVYDRALA DTEVEQLALP VATQGVADDK AALTLGDTSA VTADLDLPKT GSAGGSSISW
ASDNPSVVSE TGKVTRPAAG EPDGRAELTA TLKKGTVTDT RSFDVTVLPA FDDETAARQA
AEDLVVHNID DVRGNLTLPA DGSFGTHVTW SSAHPDVVAA DGTVHRPAHG AGAADVELTA
TVTKGEATAT RTLTAKVPEL PAKQALKGYM FSYFTGEGTS DGEQLYAALS KGNDPLKWRE
LNDGKPVLTS TLGEKGLRDP FIIRSPEGDK FYQIATDLRI YGNGDWDASQ RTGSKSIMVW
ESTDLVHWTD QRLVKVSPDS AGNTWAPEAF YDEQRGEYVV FWASKLYDNE AHSGDTYNRM
MYATTRDFHT FSEPKVWIDR GYSVIDSTVI QHGGTYFRLS KDERNNSSST PNSKFIFEEK
SDSLLDTSWT PVAEGIGKGA MNAAEGPLVF KSNTEEKWYA FLDEFGGRGY IPFETTDLDS
GVWTPSTGYD LPAKPRHGTV LPVTQAEYDR LLRAYQPDQL VDSVEDIAVK TRIGDAPVLP
ATVIAKYADG VERPVSVDWA DVPESAYEQA GTFTVTGSLP EGGTLKAEVT VSAEGPDVPA
DLLLDYDFDE TGGNIARDSS GHGYHGTYVR TPDFGTGVDG GSFKMSGGTS SSTTSPYVRI
PNGVLKNADS VTVSTHVKWK GGDNFQWLFG LGPDSNKYLF ASPSNGGGKL FSAITEATWS
GEKQMTAGSR LTPGEWQHVT VTVDSATETA VLYVNGIEAA RATGVTIKPS ELYDSSKGYS
GYIGKSLYSP DPYFGGEVDD FRIYNRALAP TEVLELSGNT TGIAAATHPA LKTDAIIDDA
AGKITLPLAE GSDLTALAPE FALAHGASIS PASGTLHDFT EPVTYEVTGS DGAKRTWKVT
ALEMKSPVLP GLNADPNIVR FGDTFYIYPT TDGFPGWSGT QFKAYSSTDL VHWKDHGVIL
DLGPDVSWAD SRAWAPTMAE KNGKYYFYFS ADANIGVAVS DSPTGPFKDP LGKPLLKAGQ
LTGQMIDPAV FTDDDGTSYL YFGNGRAYVV PLNDDMTSLD STKIKDITPS GYNEGTFVIK
RKGTYYFMWS ENDTRDENYR VAYATGSSPT GPWTKQGVIL EKDLSLGIKG PGHHSVVHVP
NTDDWYIAYH RFAIPGGDGT HRETTVDKLE FDADGLIEKV VPTLTSIDPV TVVHAGSDAD
GTEGDAIRIS GTLSGAGSPK WTIEKGAPCA FADAGAAATT LTCRDDGTYE VTLTGGRSSD
TATVTVGNAA PAITSAHGPA SPVAANRATA VSAAFGDPGS ADTHTCTVDW KDGGEPTRGT
VSDSRCTATH TYTTAGIRRP VVTVTDDDGA SDRRTLPELV VYDRAAGPAA GVGIVTSAAG
AYPAQPGLTG KAAFSFTADY RRNADVPTGK VTFDFGAARL KFRSTGSDWL VVTKSRAVYQ
GSGTVNGAAG YGFRITATDG PDTFRIEVWK KSTGAVVYDN ATAATVTGFV TVGGPRL
//
