ID   A0A0L8LPX0_9ACTN        Unreviewed;       876 AA.
AC   A0A0L8LPX0;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=von Willebrand factor A {ECO:0000313|EMBL:KOG40238.1};
GN   ORFNames=ADK74_25600 {ECO:0000313|EMBL:KOG40238.1};
OS   Streptomyces decoyicus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=249567 {ECO:0000313|EMBL:KOG40238.1, ECO:0000313|Proteomes:UP000037606};
RN   [1] {ECO:0000313|Proteomes:UP000037606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 2666 {ECO:0000313|Proteomes:UP000037606};
RG   Consortium for Microbial Forensics and Genomics (microFORGE);
RA   Knight B.M., Roberts D.P., Lin D., Hari K., Fletcher J., Melcher U.,
RA   Blagden T., Winegar R.A.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KOG40238.1}.
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DR   EMBL; LGUU01000249; KOG40238.1; -; Genomic_DNA.
DR   RefSeq; WP_053209898.1; NZ_LGUU01000249.1.
DR   AlphaFoldDB; A0A0L8LPX0; -.
DR   PATRIC; fig|249567.6.peg.5673; -.
DR   Proteomes; UP000037606; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        264..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          677..866
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|SMART:SM00327"
FT   REGION          360..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   876 AA;  93963 MW;  96FA7D6FC80E270C CRC64;
     MSEYDARGKV NRALLICVDD YRTLRPLPAV KDNARELERA LLAPGTDLFT KGEVVTCRPQ
     EPWEVEQALD TVVQEARGLL LVYFSGHGRV GRDGGNLQLM VGASERRHKT VSWQDTVLSY
     LDNARADRIV IVLECCYAGN GSEAFHSCRN PTSLLMAAQP NRRIFSGEEP TGGSVFTRAL
     VQTLERGIPG KRFVTFEDLV RDLREQLAGE RTPMGDVWEP RSAKHNTVDD VILSFATPED
     RPPTPLRIRL RRWLKSYFRH WPRLLLILAI VFVPATTGVV LLHLANGEAP CPPALELRLL
     TAPEAEPALR QAAFDYEMSQ ANTRPLSGEG DLPDGCRRAQ ITVYSAAKDQ VAQGFAAADR
     WQGEAHGTGK GRPGDQGIDP LHRPGPQPDI WIPESTADYY EARRGMPATG SPATLHYSAP
     VAYTPLVVGI PARRRLDDVE LAGASWQELL TGTDSTHHDL KLLRPSPVLS GTGLLHTIGL
     YLAHDGSGTA TGAPDLTLAR HAEERLAAPG SQYAGSTELL CSLRPDTDAA GSVDRTKSAP
     LVSEKSLADY NLGRATGSCP ALDAPLPLRD RYVAYYPANV PALDHPLVRV DWQGATDATP
     RQAAVADFAQ WLRARDGGQR TLTAQGYRGV RDSGPRQGSP LLDSRADVSP LASTIPFTAD
     PGQVSRVLDG YDKAQRSSQV LILMDASTSM ADGGKLPIAL SAAGRAVELV GARHTYGLWT
     FPDRAHPEDR DAVRELVPLG SADPAPGKAA LARIAGSPDG ELVDHGAAME EALTRAVRKM
     KTSSATNKAI VLILDQDDGA GAGRAAGVER TLSALVKEGP RVPLLVLAMG RSGCDTFALQ
     QLAGASHGQC VPSGPQAVDT LAGRIASIGT ATKGDR
//