ID A0A0L8LV23_9ACTN Unreviewed; 334 AA.
AC A0A0L8LV23;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Methyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ADK74_18385 {ECO:0000313|EMBL:KOG41996.1};
OS Streptomyces decoyicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=249567 {ECO:0000313|EMBL:KOG41996.1, ECO:0000313|Proteomes:UP000037606};
RN [1] {ECO:0000313|Proteomes:UP000037606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2666 {ECO:0000313|Proteomes:UP000037606};
RG Consortium for Microbial Forensics and Genomics (microFORGE);
RA Knight B.M., Roberts D.P., Lin D., Hari K., Fletcher J., Melcher U.,
RA Blagden T., Winegar R.A.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOG41996.1}.
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DR EMBL; LGUU01000231; KOG41996.1; -; Genomic_DNA.
DR RefSeq; WP_030074982.1; NZ_LGUU01000231.1.
DR AlphaFoldDB; A0A0L8LV23; -.
DR PATRIC; fig|249567.6.peg.4024; -.
DR Proteomes; UP000037606; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 24..96
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 118..314
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 246
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 334 AA; 36157 MW; B02DD0E5D8169DDE CRC64;
MFKTTTDAEL AGNPIDEVIG STIRYAALTS AAKLGIFTAL EEDGPKTLDE LAAAIGASTD
GTRAVADVAA VLGWLTLEDG RYRNGPLAER WLGKNAEYDF TPALLWAYEL TNVMWDLPQA
VRDGKPDRSL WERWADNPDA GRDFSAYMRV KSRLTVQSIV DAVPLPEGAR RLLDLGGSHG
LHSMAMCRRH PDLSATILDL PEALADTGTA IAEAGLTDRI TLERGSFLSG DLGTGYDVVF
LFEIVHNHTD EENRDLVARA AKALRPGGRI VVLEDVRGEE LDEHNAAFSL AMYACSGDRT
YSLPEISGWL TDAGLKTVER IALPSSVSLV VGTK
//
