ID A0A0L8LY83_9ACTN Unreviewed; 1287 AA.
AC A0A0L8LY83;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Amino acid adenylation protein {ECO:0000313|EMBL:KOG43111.1};
GN ORFNames=ADK37_02570 {ECO:0000313|EMBL:KOG43111.1}, AQJ84_16285
GN {ECO:0000313|EMBL:KUN97676.1};
OS Streptomyces resistomycificus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=67356 {ECO:0000313|EMBL:KOG43111.1, ECO:0000313|Proteomes:UP000037251};
RN [1] {ECO:0000313|EMBL:KOG43111.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 2290 {ECO:0000313|EMBL:KOG43111.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000037251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2290 {ECO:0000313|Proteomes:UP000037251};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KUN97676.1, ECO:0000313|Proteomes:UP000052992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40133 {ECO:0000313|EMBL:KUN97676.1,
RC ECO:0000313|Proteomes:UP000052992};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces resistomycificus DSM 40133, type
RT strain for the species Streptomyces resistomycificus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOG43111.1}.
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DR EMBL; LGUS01000012; KOG43111.1; -; Genomic_DNA.
DR EMBL; LMWZ01000014; KUN97676.1; -; Genomic_DNA.
DR RefSeq; WP_053190232.1; NZ_LGUS01000012.1.
DR STRING; 67356.AQJ84_16285; -.
DR PATRIC; fig|67356.5.peg.557; -.
DR eggNOG; COG1020; Bacteria.
DR Proteomes; UP000037251; Unassembled WGS sequence.
DR Proteomes; UP000052992; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR000415; Nitroreductase-like.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037251}.
FT DOMAIN 939..1014
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1287 AA; 139839 MW; 735CA8BF7805A934 CRC64;
MSTRAPISGV SHMGVSLPAL LAHQARLRAD DIAVTLPQTS GERRHLTFGG LDAAARRLGG
HLARLGVGPD SCVGLFTEPS AELMTGVWGI LTAGAAYLPL SPDYPEDRLR FMVEDSGARV
VVTQDHLRER ALALVPAGTT VVTASDIPDL PAAELPQSRG HHLAYVIYTS GSTGRPKGVM
IEQRSIVSQL QWLANFGHLG PDVAILQKTP MSFDAAQWEI LAPVTGARVV MGTPGIFRDP
EAIVTAICEH RVTALQAVPT LLQALVDTEQ LGACASLTRV FSGGEALTRT LARDLFAALP
GVSVVNLYGP TETTINATSH WIDPDTLDPD AAGEAPSGIV PIGTPADNVT CYILDGNRQP
VDIGESGELF LGGAQVARGY IGLPEQTEAR FVTSPFNPTE RLYRTGDLCQ WNPDGTIQFM
GRTDNQVKLR GYRVELEEVA SRIEEHSWVR RAASVVTDDP RTGSKALVAA VELNERTAAV
MDQGRGDAAH HQSKASKLQV RAQLSNPGLR EPAELAGREA VRLPGREATA AQRREAFARK
TYRFYDGPAV TAADVLDLLA PRPASSYSRP LTELTMTELG EILRWFGPFR SAERLLPKYA
YASPGALYAT QLYLEVCGLP GLAAGLYYHH PVDHTLVRIG DVDEDLAAPG LRVHFLGKVR
AIEPVYKNNI AEVLEFEAGH MVGVFEEVLP GHGLTIGPYG FEPGVKDRLD VADEDLYLGT
FEITAQHGRT RPDQVDLYVQ AHDERVQGLA AGLYRHRNGE LEPLGSDVVE KRHVIAINQG
VYERAAFGVS AVARTDADWL RYVVLGTALH HLQRRPGFGL MSSGYSSKSG HPLPASRRLD
DLLAAAGEPA APASYFFVGG RISGEQAGHE GMNEDAVHTK GPAEMIRDDL ARFLPDYMIP
ARVLVVNELP LTANGKIDAK ATARLPEIAQ ARTSAAYVAP ATATEHWLAG EWGRALKYED
VSTQDEFFAS GGNSLHAVAL VNRINREFGI TLPLQVVFES PKLADLAARV DEGAPSRVSR
LVPLHPGDAP DRPVFCWPGL GGYPMNLRLL GREAAADRPF YGVQAHGINP GEMPYGTIRE
MAMADVAEIR RTQPSGPYTL WGYSFGARVA FEAAWQLEQF GEKVDRLLLI CPGNPRVRTE
DGRQWGREAS YANPAYVTIL FSVFTGTIHG PELRECLTRA VDEDSFVGYV AGLLPELGAE
TIRRITRIVT ETYEFEYSFR ELRERRIEAP VTIFKARGDD YSFVEDSSGY SAAPPRIVEL
DGDHYAVLKP HGVSELVAAI HDVTGPR
//
