ID A0A0L8LZL7_9ACTN Unreviewed; 4778 AA.
AC A0A0L8LZL7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:KOG43618.1, ECO:0000313|EMBL:KUO00190.1};
GN ORFNames=ADK37_00310 {ECO:0000313|EMBL:KOG43618.1}, AQJ84_08685
GN {ECO:0000313|EMBL:KUO00190.1};
OS Streptomyces resistomycificus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=67356 {ECO:0000313|EMBL:KOG43618.1, ECO:0000313|Proteomes:UP000037251};
RN [1] {ECO:0000313|EMBL:KOG43618.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 2290 {ECO:0000313|EMBL:KOG43618.1};
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000037251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2290 {ECO:0000313|Proteomes:UP000037251};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KUO00190.1, ECO:0000313|Proteomes:UP000052992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40133 {ECO:0000313|EMBL:KUO00190.1,
RC ECO:0000313|Proteomes:UP000052992};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces resistomycificus DSM 40133, type
RT strain for the species Streptomyces resistomycificus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOG43618.1}.
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DR EMBL; LGUS01000001; KOG43618.1; -; Genomic_DNA.
DR EMBL; LMWZ01000004; KUO00190.1; -; Genomic_DNA.
DR RefSeq; WP_053190120.1; NZ_LGUS01000001.1.
DR STRING; 67356.AQJ84_08685; -.
DR PATRIC; fig|67356.5.peg.67; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000037251; Unassembled WGS sequence.
DR Proteomes; UP000052992; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037251}.
FT DOMAIN 965..1039
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2012..2086
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3189..3266
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4252..4327
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2082..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3261..3280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4046..4065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4778 AA; 512481 MW; CD1FFD36708B1082 CRC64;
MPHAESDRTT AAGMPLTGGQ SGIWLAQQIE PDSSAYHLAY VLELRGDVDL ARLVAAVRGA
VGEAEAPHVR FTAERGTPWQ TVARFPVDVL VLDLRGEPDP EQSAAAWMDT DRRRTAPLEA
GPLFAQAVLR LADDRVLWYQ RYHHVVVDGL GVVLLTRRAG ELYTAGDQDS AAPDWALTHL
VDADEAYRRS AQHRADRAYW LDRLTGRPEP VRLVERAPTP MTRRLRRTTG LSPRTVARLD
AVARGAGTRL SRLLVAAVAA YLHRTSGARD LVLGLPVTAR PDTVPAVPGM VSNVVPLCLS
VHPGTTGAEL VAHVRQAVTE AVEHGRYRAE DLARDLGLAD GVAELVGPTV NVLPRTADLR
FGDHVSELHP AWLGPVSDLA FSFSEAPPGQ GVRLHLDADA DVCDEQALHD HERRFLSLLD
ALAEDPDRPV GRIDLTDGDE RALLLDEFGV APREVPEVSW PAAFEDRVRR APETVALVCE
DRELTYAELN AAANRLARLL VSRGVRAEDI VAVALPRSPE LVVCLLAVLK TGAAYLPLDA
DHPQDRIAYM LADAGARAVV TVRDLAAELP GEPVVARVLL DDPATAAECA AQDASDPGLP
IPLGQAAYVI YTSGSTGRPK GVVVTHDGVG SLIATATDRI GVDSDSRVVQ FASVGFDVTV
WDLIMSLCVG GRIVVVPAER RVAGPALTEY VARHRATHMI LPPSLVSALP RDCPLPDGAV
LVVGTEAVPS ELIARWSGRM RVVVAYGLTE ASVNSTLWLA DPGRPGPAPI GRPDPNTRAY
VLDAALRPVP VGAEGELYVA GRGLARGYLG RPALTSERFV ADPFGAPGTR MYRTGDRVRW
STDGNLEFLG RSDGQLKVRG HRIEPGEVES AFMACPGIAQ ATVLLREDHR SVKRLVAYLV
TEPDGTDADA AVAAARAQVA DILPDFMVPS AVVVLDGPLP LTPNGKLDGR ALPAPGWTAL
SGADAPTSPV ERRLADLFAE VLGLPSVGVH DSFFELGGDS IVAIQLVNRA RAAGLPITPR
DVFRQRTVAA LARAADRDAG ATTPATGVDL DENALPVSPL QEGFFFHARF DDQATDVYLV
QELFELTGPV DPDLLRRALQ TLLDRHPLLR ASFRQLPDGR VVQRLAEHTT LPWRQADIAG
TGWDEVLAAD RAEPFDLARP PLLRAALLRD GRRHRLLLTL HHIIADGWSV SVLLRELLAL
LRREELADPV GPHPYLAWLA SRDREAAREA WRRTLAGLAG PTLLAESLAT ANEQEGPVRP
AHLDVPLPAG LTTDLTNRAR THGLTTSTVV HGLWGLLIGG LTGSQDVVFG STVSGRTTEV
DGLDRAVGLF VNTVPARVRP RPEESLTALL RRVQDEHAAL LDHQHLGLAD IQRTAGGGEL
FDTLVVFENQ PAADLDSGHG TDAPRVTGAE VYDAVHYPLA LIVDPGGDTG LRLRFKHDAT
LLDGPTMEAL AGRFVDLLRT FVSDPDRPVA RTCLLSGREL RRVAESNDTA RPVPDATLAS
LIAAQVVRTP WATAVVFEGT ELSYAELDAR AEALARRLRA HGAGPERYVA VAVPRSAELM
VALLGVLKAG AAYLPVDLDY PADRIAFMLG DSGARTVVTT AEAAGRLPEG PGPERLLMDR
PVPEHEADLP VTPGEAAGPD HPAYLIYTSG STGRPKGVEV THRAIVNRLA WMQGEYGLGA
DDRVLQKTPS SFDVSVWEFF WPLTQGAAVV LARPDGHRDP AYLAGLIHAE RITTTHFVPS
MLAAFLQVME TGTGRPDGPN WSSSLRRVFC SGEALTGADA RRWSELTSRA GHAPVPLHNL
YGPTEAAVDV TYFPYEGGGE GLVPIGRPVW NTRLHVLDAF LRPVPDGVPG ELYLAGLQLA
RGYHGRPGLT AERFVADPSG APGERMYRTG DLVRRRADGA VEYLGRTDRQ VKIRGNRVEP
GEIEALLGGL PGVARAAVVV RDGALVGYAV PVPCPQAPGT EALRDALADA LPPAMVPSAV
VVLDELPLTP SGKLDQNALP APAVAPVAAG RGPGDERERA LCEIFAIVLG VPGIGADDDF
FTLGGDSITS IAVATQARER GLEIAPRDVF ERRTPAALAA AARDVRADAT PADVTVPADA
TPADGTDRSD GTDRSDATDS AGVTVRAEEA GQAAAALKAV LLQQERSGAA VDPALRALLD
QLTAAAGPPG EPRPPAPLGG AELTPEETAR VEEAAGGLTV ADIWPLSPLQ EGMYFHATYD
AGEALDVYLS QETLDLDHRV DAGRLRAACR TLLERNTSLR AGFVSDGMRR PVQFIADGAE
IPLVEQDLSA LPAEEQRART DALLAADRRR RFDLSVPPLA RLLLIRLGDG RDRLVVTHHL
IVWDGWSAWL FLEELFTLYD RAGDATGLPA PGSYRDYLAW LDRQDTDAAL AAWRGALAGF
DEPTLVAPTG RDSGPVIPAD FDAVLPQATG DRLRTVARRH GLTLNTVLNA AWGLVLCAMT
GRGDVVFGTA VAGRPADVPH ASGIIGMFLN TVPARVALDP HEPLLDLLRR TQAERAAVMP
YEYVGLGSLQ QETGHRRLFD TLFVLRSADG EQRAATLRRR HGITDVTNVD GTHFPLTLIV
TPESRLRVTL AARPDLFDAQ DATLILARFT AVLEQLAEAL DAPADGATPT ARVDLLLPAE
RTALATRWET SRAPLPNTTI ADMLAVQTAG TPDAVALVFG EHALTYAELD ARINRLARLL
LARGAGPEKV VALALPRSIE MVTALFAVLR TGAAYLPLDL DHPADRLRLM VEDTGPVSLV
STTAVAPALR GEAGPPAPEL LLDDPAVAAE LAALPDGEIT DAERPAFAHD VPDRLEHPAY
VIYTSGSTGR PKGVVTPYRG LTNMQLNHQR EIFDPAIASA GGRRLRIAHT VSFAFDMSWE
ELLWLVEGHE VHVCDEELRR DAEALVAYCD RHRVDVVNVT PTYAQLLIEE GLLEQDEATG
RHRPALVLLG GEAVSDAVWT RLRVTEGTYG YNLYGPTEYT INTLGGSTTD SATPTVGLPI
RNTRAHVLDA MLRPVPPGCP GELYIAGTGL ARGYHDRPGL TAERFVADPF GAPGERMYRT
GDLVRQRPDG LLDFLGRTDD QVKIRGYRVE PGEIATALTG HPEVAHAAVV VAPSAGTKRL
IGYVVPEAGA EAGEDLARRL RDHLKAVLPD YMVPAAFMAV DTLPLTVNGK LDVRALPAPD
LSGTAASRPP RTPEEETLRA LFAEVLGLPE QAVGIDSDFF DLGGHSLLAT RLVSRVRTAL
DAELAIRDLF EAPTVAELVR RTGRPDTGGR PALTPADRPG ELPLSHAQQR LWVIQQIECT
SAAYNFPLVL RLRGAFDVDA WRAALADVTA RHEALRTLFT ERDGEVFQRV LPADEARPVV
ELLHAAEDEV TDVVDTAVRR PFDLAAELPV RATLVEIAPE DHVVVLLLHH ITTDEWSDRP
FLRDLATAYR ARTSATAPAW EPLPVQYADY ALWQRRLLGD PAGPGSLAAR QLEYWRGNLD
GAPEELDLPA DRPRPARPTF SGAEFGIEFD AETHEGLRRL ARDTGASMFM VVHAAVAALL
HRLGAGTDIP LGAPIAGRGD EALDDLVGFF VNTLVLRTDL GGDPSFTEFL ARVRETDLAA
FSHADVPFEA VVESINPTRS LSRNPLFQVM VGYHARTGDG LELPGLQAEF LPFRVDSAKF
DLVFAFTERP ATDGGPGSLG CRLEYATELY DHETAVRIGE RLRGLVAALA AAPERPVSQA
EILTLEERRL VLEDFNATAR DVEEASLPGL FARRLAEQPD AVAVVERSRS LTYAQLDARA
NRIARLLTAH GVRAESVVGV AVPRSVDMVA TVLATLKLGA AFLPLDLVHP ADRLTYMIED
SGAALVVGSE PVAGKIPDVP DVPVLLLDAP GTAADLDRLP GTPPATAAVP PDRAAYVIYT
SGSTGRPKGV VVPHEGISSL VATAVDRMGL RRDSRVLQFA SIGFDVFAFE LSMALCHGGR
LVLVSDEARV AGPALTDFLA EQRVTHMILP PSLVSALPQG CRLPDGSTVL VGTETVPPDL
FERFGATAHL ICAYGLTEAT VNSTLWPSRE HGGRPPGRVP IGRPDPNTRC YVLDERLRPV
PPGVPGELYV SGRGLARGYL GKAALTSERF VADPFGPPGN RMYRTGDRAR WQSDGNLDFL
GRVDTQVKIR GFRIELGEIE AALTGHPAVG QAAVLPHRDG DIVRLVGYAV PDSGQELDPQ
ALRAHVAGLL PEYMVPALVT ALDGPLPLTP NGKLDRRALP APDWTAMTGD ARPATATQAR
LAALFREILR LDDVGVHDNF FALGGHSMAA MRLLGRIRTE FGAELSIRDV FDALTVAGLA
AKLHGAATAR PALRPAATDP VRIVAPVQRR QWDVHRHTPG FDHALVLRSP GGLDADALRA
ALADVTARHQ PLRTAFTEHD GTVSPQDVEG PRLAVERCVD LDARIAELVA EVPDVRREAP
LRVRLLTGAD GSQAVLLTLH YLAVDEWSVV PLLRDLTTAY AARVEGRDPG WDPLPVTYAD
YARWAHEVLG DATDPESRAG SQLAYWRQAL SGVPGELPLP GDRPRPDAVD GSRRAAGHVG
FVLDAGLHTE VDLLARATGT SMFMVLHSAL AALLTAHGAG TDLPIATLVA GRTDDQLADL
VGCFFNTVVL RTDTAGDPTF ARLLSRVRET TLGALDRQDV PFDRVVGETG LPARGPQVMV
VQHEQADLEA LEGGMGSLQA VPTGAARADL TLGFHEPRGD GPVHCALIHA TDRLDTATVR
GLTDELTTLL RRAVAAPESP LSELFTAKST VSTRSDRA
//
