ID A0A0L8V831_9BACT Unreviewed; 605 AA.
AC A0A0L8V831;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=NC99_25890 {ECO:0000313|EMBL:KOH44604.1};
OS Sunxiuqinia dokdonensis.
OC Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Prolixibacteraceae;
OC Sunxiuqinia.
OX NCBI_TaxID=1409788 {ECO:0000313|EMBL:KOH44604.1, ECO:0000313|Proteomes:UP000036958};
RN [1] {ECO:0000313|Proteomes:UP000036958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK {ECO:0000313|Proteomes:UP000036958};
RA Ahn S., Kim B.-C.;
RT "Genome sequencing of Sunxiuqinia dokdonensis strain SK.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOH44604.1}.
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DR EMBL; LGIA01000159; KOH44604.1; -; Genomic_DNA.
DR RefSeq; WP_053183954.1; NZ_LGIA01000159.1.
DR AlphaFoldDB; A0A0L8V831; -.
DR STRING; 1409788.NC99_25890; -.
DR PATRIC; fig|1409788.3.peg.2670; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000036958; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:KOH44604.1};
KW Hydrolase {ECO:0000313|EMBL:KOH44604.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:KOH44604.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000036958};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..142
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 160..435
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 605 AA; 69061 MW; 1B5ECDDB41BB5625 CRC64;
MKDFKAKADL IWRVADLLRG DYKQSDYGKV ILPMTVLRRL DCVLEPTKQK VLDYLPKVDS
LKESSKDIAL NKIAGFNFHN RSQFNFEKLI ADPNNVAINL RTYINGFSTS AREIIEYFNF
DDQIDRMDDP KADILFRVVK SFQEIDLKPD RQNMADDSMQ MGYLFEELIR KFAEQSNETA
GEHFTPREVI RLMVNVLFIE DKDILTQEGI VKTLYDPACG TGGMLSVGEQ YVKELNPKAD
LKVFGQEINP ESYAICKSDM LIKGQNPSNI KFGNTFTVDG LEDEKFDYML SNPPFGVDWK
KAQKIIAAEA DKKGMSGRFG VGLPRINDGS LLFLQHMISK MKAGGTRIGI VFNGSPLFTG
AAESGESNIR RWIIENDWLE AVIGLPDQLF YNTGISTYIW IVTNHKSAER SGKVQLINAT
GAKDDELTKG GKLDFNRFWQ KMDRSLGNKR KRIVENGNER GIGFITQLYG NFEENEFCKI
LPNEFFGYWR ITVEQPLKEN GKVVKSKGKP KPDTSLRDYE NIPFLKKDAD QNLVPQTIEE
YFDAEVKPHL PEAWIDHSKT KTGCEINFTK YFYEFKPLRP LASIKADILA LEEKTLETEK
TVLDS
//
