ID A0A0L9U802_PHAAN Unreviewed; 891 AA.
AC A0A0L9U802;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Insulin-degrading enzyme-like 1, peroxisomal {ECO:0008006|Google:ProtNLM};
GN ORFNames=LR48_Vigan03g215900 {ECO:0000313|EMBL:KOM38777.1};
OS Phaseolus angularis (Azuki bean) (Vigna angularis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Vigna.
OX NCBI_TaxID=3914 {ECO:0000313|EMBL:KOM38777.1, ECO:0000313|Proteomes:UP000053144};
RN [1] {ECO:0000313|Proteomes:UP000053144}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Jingnong 6 {ECO:0000313|Proteomes:UP000053144};
RX PubMed=26460024; DOI=10.1073/pnas.1420949112;
RA Yang K., Tian Z., Chen C., Luo L., Zhao B., Wang Z., Yu L., Li Y., Sun Y.,
RA Li W., Chen Y., Li Y., Zhang Y., Ai D., Zhao J., Shang C., Ma Y., Wu B.,
RA Wang M., Gao L., Sun D., Zhang P., Guo F., Wang W., Li Y., Wang J.,
RA Varshney R.K., Wang J., Ling H.Q., Wan P.;
RT "Genome sequencing of adzuki bean (Vigna angularis) provides insight into
RT high starch and low fat accumulation and domestication.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:13213-13218(2015).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; CM003373; KOM38777.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L9U802; -.
DR STRING; 3914.A0A0L9U802; -.
DR EnsemblPlants; KOM38777; KOM38777; LR48_Vigan03g215900.
DR Gramene; KOM38777; KOM38777; LR48_Vigan03g215900.
DR OMA; WIFDEMK; -.
DR Proteomes; UP000053144; Chromosome 3.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 5.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053144};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 50..128
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 155..332
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 340..545
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 589..776
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 891 AA; 102677 MW; E7E6756D0F35555A CRC64;
MELLSAVTLG CTKFMHLSGN SDIFNFSSFA FPCLVTPPSV CQALFNDLQN NHGGSTNAFT
SSEHTNYYFE VNTDGFEEAL DRFAQFFTKP LMSPDATMRE IKAVDSENKK NLLSDGWRMN
QLQKHLSDED HPYHKFSTGN WDTLEVKPKA RGLDTREELL KFYDENYSAN LMHLVIYTNE
SLDKIQNLVE EKFQDIRNTN KSCFHPCGQP CKSEHLQIVV RAVPIKQGHK LRIAWPVTPE
IHHYTEGPSR YLGHLIGHEG EGSLYYILKK LGWATSLSAG ESDWSLDFAF FSVVIDLTDS
GHEHVEDIIG LLFKYIELLQ HSGVCEWIFQ ELSAICETKF HYQDKIPPSD YVVDIASNMQ
FYPVKDWLTG SSLPFKFSPN VIHMILGQLS ADNVRIFWVS KNFEGHTDKV EPWYGTGYSL
EKITGSVIQG WMASAPNENL HLPAPNNFIP TDLSLKVVQE KVKFPVLLRR STYSALWYKP
DTLFSTPKAY VKIDFNCPYA GSSPEAEVLV HIFTQLLMDY LNDYAYYAQV AGLYYSITHT
DGGFQEMVTK EYQNMKYQQP YQQAMNYCSL ILQDHTWPWI EQLDLLPALQ VEDVAKFVPL
MLSRTFLEFY IAGNIESHEA ESMVKHVENV LFNYSKPLCK PLFSSQHLVN RVVKLKSGMN
YFYPSECLNP ENENSALLHY IQVGRDDFKL NVKLQLFALV AKQPTFHQLR SVEQLGYITV
LLQRNDCGIR GLQFIIQSTE KSPGNIEQRV EAFLKMFETK IYEMTIDEFK SNVNALIDVK
LEKHKNLREE SSFFWREIND GTLRFDRRDH EVEALRQLTL QELIDFFNEY VKVGAARKKT
LSVRVHGNRH SSEYKAEVSD PHLARIDNIF TFRRSQSLYG SFKGLSGQMK L
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