ID   A0A0M0BPT7_9ARCH        Unreviewed;       316 AA.
AC   A0A0M0BPT7;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AC480_01205 {ECO:0000313|EMBL:KON30385.1};
OS   miscellaneous Crenarchaeota group archaeon SMTZ1-55.
OC   Archaea; Candidatus Bathyarchaeota.
OX   NCBI_TaxID=1685133 {ECO:0000313|EMBL:KON30385.1, ECO:0000313|Proteomes:UP000037456};
RN   [1] {ECO:0000313|EMBL:KON30385.1, ECO:0000313|Proteomes:UP000037456}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMTZ1-55 {ECO:0000313|EMBL:KON30385.1};
RA   Lazar C.S., Baker B.J., Seitz K.W., Hyde A.S., Dick G.J., Hinrichs K.-U.,
RA   Teske A.P.;
RT   "New insights into the roles of widespread benthic archaea in carbon and
RT   nitrogen cycling.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KON30385.1}.
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DR   EMBL; LFWX01000014; KON30385.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0M0BPT7; -.
DR   PATRIC; fig|1685133.3.peg.1234; -.
DR   Proteomes; UP000037456; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          5..183
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          188..270
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   SITE            141
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ   SEQUENCE   316 AA;  34339 MW;  E48C14049E3759D1 CRC64;
     MDIENVACVG AGLIGQSWAT LFASKGCAVN VQDQQEAILT SALTRIRSNL GFLARNGLLD
     GADPQEVLQG VTVTTSLVEA VKNVEYVQES VFEEYDVKKA VFREMDAVAP KDAIFASSSS
     GLLITEIQRV TTQPDRCLIA HPFNPPHLIP LVELVPGEQT APDVVQAVSD FMRRIGKAPV
     VLRREAPGYI ANRLSAALWR EAIDLVDQGV ASVEDVDKAL RMGPALRWAL MGVHLTYHLG
     GGPGGIEHFV DTLGPAFASW WKTMNTWTSI PASAASKVIE GVTNMNVVQT KSREEIVRWR
     DEKILEILKV VSGSQP
//