ID A0A0M0ES69_9BACI Unreviewed; 222 AA.
AC A0A0M0ES69;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Adapter protein MecA {ECO:0000256|HAMAP-Rule:MF_01124};
GN Name=mecA {ECO:0000256|HAMAP-Rule:MF_01124};
GN ORFNames=AKG34_04625 {ECO:0000313|EMBL:KON68170.1}, CN689_03160
GN {ECO:0000313|EMBL:PEJ36857.1}, DTO10_18720
GN {ECO:0000313|EMBL:AXN40201.1};
OS Peribacillus butanolivorans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Peribacillus.
OX NCBI_TaxID=421767 {ECO:0000313|EMBL:AXN40201.1, ECO:0000313|Proteomes:UP000260457};
RN [1] {ECO:0000313|EMBL:KON68170.1, ECO:0000313|Proteomes:UP000037522}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18926 {ECO:0000313|EMBL:KON68170.1,
RC ECO:0000313|Proteomes:UP000037522};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Fjat-14236 dsm 18926.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PEJ36857.1, ECO:0000313|Proteomes:UP000220106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AFS003229 {ECO:0000313|EMBL:PEJ36857.1,
RC ECO:0000313|Proteomes:UP000220106};
RG Agbiome Team Llc;
RA Bleich R.M., Kirk G.J., Santa Maria K.C., Allen S.E., Farag S., Shank E.A.,
RA Bowers A.;
RT "Large-scale bioinformatics analysis of Bacillus genomes uncovers conserved
RT roles of natural products in bacterial physiology.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AXN40201.1, ECO:0000313|Proteomes:UP000260457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHB-7a {ECO:0000313|EMBL:AXN40201.1,
RC ECO:0000313|Proteomes:UP000260457};
RA Zhao H., Xu Y., Lin S., Spain J.C., Zhou N.-Y.;
RT "The molecular basis for the intramolecular migration of carboxyl group in
RT the catabolism of para-hydroxybenzoate via gentisate.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC aggregated proteins to the ClpC protease or to other proteins involved
CC in proteolysis. Acts negatively in the development of competence by
CC binding ComK and recruiting it to the ClpCP protease. When
CC overexpressed, inhibits sporulation. Also involved in Spx degradation
CC by ClpC. {ECO:0000256|HAMAP-Rule:MF_01124}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC Rule:MF_01124}.
CC -!- DOMAIN: The N-terminal domain has binding sites for ComK and probably
CC for unfolded/aggregated proteins; the C-terminal domain interacts with
CC ClpC. {ECO:0000256|HAMAP-Rule:MF_01124}.
CC -!- SIMILARITY: Belongs to the MecA family. {ECO:0000256|ARBA:ARBA00005397,
CC ECO:0000256|HAMAP-Rule:MF_01124}.
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DR EMBL; CP030926; AXN40201.1; -; Genomic_DNA.
DR EMBL; LGYA01000001; KON68170.1; -; Genomic_DNA.
DR EMBL; NUEQ01000007; PEJ36857.1; -; Genomic_DNA.
DR RefSeq; WP_053345000.1; NZ_NUEQ01000007.1.
DR AlphaFoldDB; A0A0M0ES69; -.
DR STRING; 421767.AKG34_04625; -.
DR KEGG; pbut:DTO10_18720; -.
DR Proteomes; UP000037522; Unassembled WGS sequence.
DR Proteomes; UP000220106; Unassembled WGS sequence.
DR Proteomes; UP000260457; Chromosome.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0045808; P:negative regulation of establishment of competence for transformation; IEA:UniProtKB-UniRule.
DR GO; GO:0042174; P:negative regulation of sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.1950; -; 1.
DR HAMAP; MF_01124; MecA; 1.
DR InterPro; IPR038471; MecA_C_sf.
DR InterPro; IPR008681; Neg-reg_MecA.
DR PANTHER; PTHR39161; ADAPTER PROTEIN MECA; 1.
DR PANTHER; PTHR39161:SF1; ADAPTER PROTEIN MECA; 1.
DR Pfam; PF05389; MecA; 1.
DR PIRSF; PIRSF029008; MecA; 1.
PE 3: Inferred from homology;
KW Competence {ECO:0000256|HAMAP-Rule:MF_01124};
KW Sporulation {ECO:0000256|HAMAP-Rule:MF_01124}.
SQ SEQUENCE 222 AA; 26507 MW; FB92D936997955E8 CRC64;
MEIERINDDT VKFYISYIDI EERGFDREEI WYSRERSEEL FWEMMDEVHQ EEEFMIEGPL
WIQVQALEKG LEVLVTKAQL AKDGQKLELP LSEDKLKDLN VSEKMDTLLD QHFHDKDEES
GITFEDGMIE FITIFEDFED VISLSKRHGL DSWTTKLYVY QNKYYLYIEF SEAEIDEEEI
DNILSLLLEY SQESPITVHM LDEYGKIVIE NDVFATVDKY FV
//
