ID A0A0M0HW17_9VIBR Unreviewed; 787 AA.
AC A0A0M0HW17;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=AKJ31_17370 {ECO:0000313|EMBL:KOO06270.1};
OS Vibrio hepatarius.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio; Vibrio oreintalis group.
OX NCBI_TaxID=171383 {ECO:0000313|EMBL:KOO06270.1, ECO:0000313|Proteomes:UP000037530};
RN [1] {ECO:0000313|Proteomes:UP000037530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19134 {ECO:0000313|Proteomes:UP000037530};
RA Giubergia S., Machado H., Mateiu R.V., Gram L.;
RT "Vibrio galatheae sp. nov., a novel member of the Vibrionaceae family
RT isolated from the Solomon Islands.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO06270.1}.
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DR EMBL; LHPI01000019; KOO06270.1; -; Genomic_DNA.
DR RefSeq; WP_053410346.1; NZ_LHPI01000019.1.
DR AlphaFoldDB; A0A0M0HW17; -.
DR STRING; 171383.AKJ31_17370; -.
DR PATRIC; fig|171383.3.peg.3550; -.
DR OrthoDB; 5807460at2; -.
DR Proteomes; UP000037530; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05784; DNA_polB_II_exo; 1.
DR CDD; cd05537; POLBc_Pol_II; 1.
DR Gene3D; 2.40.50.590; -; 2.
DR Gene3D; 6.10.140.1130; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF21474; DNApolII_N; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 109..296
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 378..758
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 787 AA; 89917 MW; 62F9628F8CCE3253 CRC64;
MTINQGFLLT RQARDVSGTT NIDLWLATEQ GPAQLIIEGE KPVFFVLQQD TALIEEQIAN
MAIPAELKPL PLHSFDSEPL AACYCATVKD AQALSQALKL QELLVLEDDI RLADRYLMER
FIKGSVEFTG TGQSRNGYQR ITNVKCRQGD YTPQLKVVSL DIECSEKGIL YSIGLDSPLD
SRVIMIGEPQ PAETSIEWVK DERELLLAMV NWFKLFDPDV IIGWNVIDFD FRLLHKRAEW
NKLKLYIGRG NQASYFRTSN TTQQGFISIP GRVVMDGIDT LKTATYHFRS WSLESVSQEL
LGEGKQIHNV HDRMDEINQM FKNDKPSLAK YNLQDCVLVN KIFAHTHLLE FAIERSRLTG
VELDRVGGSV AAFTNLYLPQ IHRAGYVAPN LHPENWIASP GGYVMDSIPN LYDSVLVLDF
KSLYPSIIRS FLIDPMGLIE GLKLEIGKAD NQAVPGFRGG QFDRRKHFLP KMIEDLWAAR
DVAKKNNEKA FSQAIKIIMN SFYGVLGSSG CRFFDTRLAS SITMRGHEIM KQTKRLIEDK
GYQVIYGDTD STFVSLNGQF SQQEADKVGN QLVEHINQWW TQHLKQEYNL TSILELEYET
HYRKFLMPTI RGQETGSKKR YAGLIGEGEQ KRIVFKGLES ARTDWTPLAQ RFQSNLYSMV
FHDQDPSEYV RDTVERTLAG EFDDELVYQK RLRRKLHEYQ KNIPPQVRAA RMADEINAQL
GRPLQYQSKG RIEYLITVSG PEPKEYLKST IDYQHYIDKQ LKPVAEAILP FIGLDFTSLS
EPQLGLF
//
