ID A0A0M0J9G5_9EUKA Unreviewed; 635 AA.
AC A0A0M0J9G5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
DE Flags: Fragment;
GN ORFNames=Ctob_002036 {ECO:0000313|EMBL:KOO22868.1};
OS Chrysochromulina tobinii.
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Prymnesiales;
OC Chrysochromulinaceae; Chrysochromulina.
OX NCBI_TaxID=1460289 {ECO:0000313|EMBL:KOO22868.1, ECO:0000313|Proteomes:UP000037460};
RN [1] {ECO:0000313|Proteomes:UP000037460}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP291 {ECO:0000313|Proteomes:UP000037460};
RX PubMed=26397803; DOI=10.1371/journal.pgen.1005469;
RA Hovde B.T., Deodato C.R., Hunsperger H.M., Ryken S.A., Yost W., Jha R.K.,
RA Patterson J., Monnat R.J. Jr., Barlow S.B., Starkenburg S.R.,
RA Cattolico R.A.;
RT "Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin:
RT Metabolic Tools for Enhanced Algal Fitness in the Prominent Order
RT Prymnesiales (Haptophyceae).";
RL PLoS Genet. 11:e1005469-e1005469(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|RuleBase:RU366025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KOO22868.1}.
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DR EMBL; JWZX01003243; KOO22868.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0M0J9G5; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000037460; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF702; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU366025, ECO:0000313|EMBL:KOO22868.1};
KW Protease {ECO:0000256|RuleBase:RU366025};
KW Reference proteome {ECO:0000313|Proteomes:UP000037460};
KW Thiol protease {ECO:0000256|RuleBase:RU366025};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025}.
FT DOMAIN 109..517
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 354..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KOO22868.1"
SQ SEQUENCE 635 AA; 65728 MW; E918CD5EF440635B CRC64;
VAEECNLVVG TFALCSNSFT LKLDDPGADA TKLLEIGCTQ KQRLRVEGIN GRIPEAAAST
AGSGSSVAAQ ALGTVALWSA GRADGQQHVY GPLARGIASS AEVNADGFIG LINQGATCYL
SSLVQSLFMT PQFRAAMYDL GAPTAGSGVI SRELQRVFVQ LQTSKAQAVD TKALTGSFGW
TQADAFMQHD VQELLRVLFD ALETELEGSA QYEHIRRIYR GEWCDYVRCK TCGTTSSRPS
AFDDVNLAIR TFDAAQTPIR SLAAAIEAFI EPETLEGDNA YHCEHCASKQ PALKGLRFTM
LPPVLCLGLK RFDFDFAELR RVKLHHSVAV PAMLSASTFL EDRAVRQAKR KLAGDNFEAD
SGEGGSSTDA VSSPEPEVSL ECNDGAAGGD ISNGDGGLTE GGAGDDGEPA SGEAAGGQAA
SGKAASAVAS GEAASGEGGN STSSAADQYE LFSMLMHSGS ALAGHYFCFI KDLSSGTWYK
FNDSSVSLAT DSQLQAAMGA TENGSAGSTY MVFYRRVDSA EPLVPPVNVP PGLQEASLAG
PIEGFGHQSS SSSDAMMVGA AESSSTAYTS DAPGSAGTSS TSASSTDPVC GPSLIGPMPQ
GVVWPEIGAC SSLATTSTNS GSSSEKGVVI GRRAR
//
